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• W2222621298 abstract "Fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS) are neurodegenerative disorders caused by the pathogenic expansion of CGG triplet repeats in the FMR1 gene. FXTAS is likely to be caused by a 'toxic' gain-of-function of the FMR1 mRNA. We provide evidence for the existence of a novel quadruplex architecture comprising CGG repeats. The 8-bromoguanosine ((Br)G)-modified molecule GC(Br)GGCGGC forms a duplex in solution and self-associates via the major groove to form a four-stranded, antiparallel (GC(Br)GGCGGC)4 RNA quadruplex with (Br)G3:G6:(Br)G3:G6 tetrads sandwiched between mixed G:C:G:C tetrads. Self-association of Watson-Crick duplexes to form a four-stranded structure has previously been predicted; however, no experimental evidence was provided. This novel four-stranded RNA structure was characterized using a variety of experimental methods, such as native gel electrophoresis, NMR spectroscopy, small-angle X-ray scattering and electrospray ionization mass spectrometry." @default.
• W2222621298 created "2016-06-24" @default.
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• W2222621298 date "2016-01-06" @default.
• W2222621298 modified "2023-10-03" @default.
• W2222621298 title "Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes" @default.
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• W2222621298 doi "https://doi.org/10.1093/nar/gkv1534" @default.
• W2222621298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4797283" @default.
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• W2222621298 hasPublicationYear "2016" @default.
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