Matches in SemOpenAlex for { <https://semopenalex.org/work/W2222791424> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2222791424 startingPage "4" @default.
- W2222791424 abstract "Parasites of the genus Leishmania are the causative agents of leishmaniasis, a neglected tropical disease endemic in many developing countries as well as in the Mediterranean area. Current treatments are inefficient, associated with high toxicity, severe side effects and most importantly, the high costs associated to the treatment are far from suitable for developing countries. In this sense, there is an urgent need to find new drugs and a new drug delivery system to treat leishmaniasis. Several studies have shown that antimicrobial peptides (AMPs), components of our immune system, are able to help the organism resist to the invasion of some pathogens, including Leishmania, by having a direct antimicrobial function as well as a capacity for immunomodulation. Their specificity to microorganisms and the low probability to develop resistance, make them very good candidates for the development of a new drug formulation. Our proposal during this project is to increase the solubility and bioavailability of selected AMPs, described in the literature as having an active effect against Leishmania. We showed that hyaluronic acid (HA) derivative nanogel has an ability to entrap hydrophobic peptides. HA is naturally present in vertebrate organisms and its viscoelastic properties, biodegradability, biocompatibility and absence of immunogenicity, make it suitable for pharmaceutical and medical applications. Poster Light: Designed by Nature, Transformed by Science 2015 MIT Portugal Annual Conference 4" @default.
- W2222791424 created "2016-06-24" @default.
- W2222791424 creator A5067203138 @default.
- W2222791424 date "2015-06-19" @default.
- W2222791424 modified "2023-09-24" @default.
- W2222791424 title "Use of antimicrobial peptides and its nanogel formulations in the treatment of leishmaniasis" @default.
- W2222791424 hasPublicationYear "2015" @default.
- W2222791424 type Work @default.
- W2222791424 sameAs 2222791424 @default.
- W2222791424 citedByCount "0" @default.
- W2222791424 crossrefType "journal-article" @default.
- W2222791424 hasAuthorship W2222791424A5067203138 @default.
- W2222791424 hasConcept C134424308 @default.
- W2222791424 hasConcept C136764020 @default.
- W2222791424 hasConcept C137858568 @default.
- W2222791424 hasConcept C151730666 @default.
- W2222791424 hasConcept C178790620 @default.
- W2222791424 hasConcept C185592680 @default.
- W2222791424 hasConcept C203014093 @default.
- W2222791424 hasConcept C2776555147 @default.
- W2222791424 hasConcept C2779820397 @default.
- W2222791424 hasConcept C2780868878 @default.
- W2222791424 hasConcept C2781092759 @default.
- W2222791424 hasConcept C41008148 @default.
- W2222791424 hasConcept C4937899 @default.
- W2222791424 hasConcept C540938839 @default.
- W2222791424 hasConcept C71928629 @default.
- W2222791424 hasConcept C86803240 @default.
- W2222791424 hasConcept C8891405 @default.
- W2222791424 hasConcept C89423630 @default.
- W2222791424 hasConceptScore W2222791424C134424308 @default.
- W2222791424 hasConceptScore W2222791424C136764020 @default.
- W2222791424 hasConceptScore W2222791424C137858568 @default.
- W2222791424 hasConceptScore W2222791424C151730666 @default.
- W2222791424 hasConceptScore W2222791424C178790620 @default.
- W2222791424 hasConceptScore W2222791424C185592680 @default.
- W2222791424 hasConceptScore W2222791424C203014093 @default.
- W2222791424 hasConceptScore W2222791424C2776555147 @default.
- W2222791424 hasConceptScore W2222791424C2779820397 @default.
- W2222791424 hasConceptScore W2222791424C2780868878 @default.
- W2222791424 hasConceptScore W2222791424C2781092759 @default.
- W2222791424 hasConceptScore W2222791424C41008148 @default.
- W2222791424 hasConceptScore W2222791424C4937899 @default.
- W2222791424 hasConceptScore W2222791424C540938839 @default.
- W2222791424 hasConceptScore W2222791424C71928629 @default.
- W2222791424 hasConceptScore W2222791424C86803240 @default.
- W2222791424 hasConceptScore W2222791424C8891405 @default.
- W2222791424 hasConceptScore W2222791424C89423630 @default.
- W2222791424 hasLocation W22227914241 @default.
- W2222791424 hasOpenAccess W2222791424 @default.
- W2222791424 hasPrimaryLocation W22227914241 @default.
- W2222791424 hasRelatedWork W1931549268 @default.
- W2222791424 hasRelatedWork W1963709620 @default.
- W2222791424 hasRelatedWork W2005965523 @default.
- W2222791424 hasRelatedWork W2146999020 @default.
- W2222791424 hasRelatedWork W2399806725 @default.
- W2222791424 hasRelatedWork W2406764016 @default.
- W2222791424 hasRelatedWork W2471697898 @default.
- W2222791424 hasRelatedWork W2579968578 @default.
- W2222791424 hasRelatedWork W2617375036 @default.
- W2222791424 hasRelatedWork W2749055920 @default.
- W2222791424 hasRelatedWork W2766590094 @default.
- W2222791424 hasRelatedWork W3112305246 @default.
- W2222791424 hasRelatedWork W3127474233 @default.
- W2222791424 hasRelatedWork W3164944612 @default.
- W2222791424 hasRelatedWork W3172728545 @default.
- W2222791424 hasRelatedWork W3195635744 @default.
- W2222791424 hasRelatedWork W3201957727 @default.
- W2222791424 hasRelatedWork W3202664340 @default.
- W2222791424 hasRelatedWork W585628708 @default.
- W2222791424 hasRelatedWork W2514157377 @default.
- W2222791424 isParatext "false" @default.
- W2222791424 isRetracted "false" @default.
- W2222791424 magId "2222791424" @default.
- W2222791424 workType "article" @default.