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• W2223085912 abstract "Antibiotics are one of the most successful forms of chemotherapy and saved million of lives placing most bacterial infectious diseases under control. However, this success has been compromised the continuous selective pressure exerted by antibiotics use has resulted in multi-resistance bacteria bearing resistance mechanisms to several antibiotics. Nowadays, there is an increased recognition that not only clinical settings constitute resistance reservoirs. The soil is a vast reservoir of resistance mechanisms and their associated genes, so understanding the resistant determinants present in the soil, the soil resistome, will provide information about antibiotic resistance frequencies and also emergence of new resistance mechanisms. Quinolones are an important group of synthetic antibiotics, recently plasmid mediated quinolone resistance mechanisms were established, some originated in environmental reservoirs. In this work the main goal was to study a collection of (fluoro)quinolone resistant environmental isolates, in terms of their ciprofloxacin MIC and screen them for the presence of qnr genes. With a smaller group of isolates the phenotypic impact of ciprofloxacin in growth curves/cellular viability was studied and finally detected and characterized induced variations of cell protein profiles, to study how ciprofloxacin affects, at a molecular level these bacteria. Results showed that ciprofloxacin MIC values had similar distributions in the soil samples from the two sample types from where these strains were isolated; in terms of resistance determinants results point that a qnrS gene was found in a Comamonas testosteroni isolate. In the second part of this work, Stenotrophomonas maltophilia response to ciprofloxacin was studied, and the growth curves/cellular viabilities results showed that S. maltophilia cells tolerate/resist ciprofloxacin action when in stationary growth. Significant differences were observed between cell total protein profiles from cells exposed to ciprofloxacin and the control. That study can help understand bacterial general response to fluoroquinolones, in addition to more classical genetic mutation, and also what intracellular pathways this antibiotic might trigger." @default.
• W2223085912 created "2016-06-24" @default.
• W2223085912 creator A5057126855 @default.
• W2223085912 date "2011-01-01" @default.
• W2223085912 modified "2023-09-27" @default.
• W2223085912 title "Screening of antibiotic resistance determinants in Gram-negative bacteria isolated from environmental reservoirs" @default.
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