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- W2223363962 abstract "Major depressive disorder (MDD) is a recurrent, relapsing psychiatric condition not only in adults but also in the elderly [ [1] Kessler R.C. Berglund P. Demler O. Jin R. Koretz D. Merikangas K.R. et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003; 289: 3095-3105 Crossref PubMed Scopus (6311) Google Scholar ]. The prevalence of MDD in people over 65 years-old reportedly ranges from 9% to 18% [ [2] Luijendijk H.J. van den Berg J.F. Dekker M.J. van Tuijl H.R. Otte W. Smit F. et al. Incidence and recurrence of late-life depression. Arch Gen Psychiatry. 2008; 65: 1394-1401 Crossref PubMed Scopus (153) Google Scholar ], with significant health care costs [ [3] Katon W.J. Lin E. Russo J. Unutzer J. Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psychiatry. 2003; 60: 897-903 Crossref PubMed Scopus (392) Google Scholar ]. The prognosis of MDD among the elderly is unfortunately typically poor and is characterized by high morbidity and mortality [ [4] Djernes J.K. Gulmann N.C. Foldager L. Olesen F. Munk-Jørgensen P. 13 year follow up of morbidity, mortality and use of health services among elderly depressed patients and general elderly populations. Aust N Z J Psychiatry. 2011; 45: 654-662 Crossref PubMed Scopus (16) Google Scholar ], with important side-effects reported, including increased cardiovascular risk, hyponatremia, and agitation [ [5] Coupland C. Morriss R. Arthur A. Moore M. Hill T. Hippisley-Cox J. Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry. 2013; 13: 135 Crossref PubMed Scopus (10) Google Scholar ]. Older patients appear take longer to respond to antidepressant medication, and as many as 50% of patients with MDD will not achieve remission with the first treatment [ [6] Roose S.P. Schatzberg A.F. The efficacy of antidepressants in the treatment of late-life depression. J Clin Psychopharmacol. 2005; 25: S1-7 Crossref PubMed Scopus (77) Google Scholar ]. Alternative therapeutic interventions merit evaluation for a potential role in MDD treatment." @default.
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- W2223363962 date "2016-01-01" @default.
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- W2223363962 title "Trigeminal Nerve Stimulation (TNS) for Major Depressive Disorder in the Elderly: An Open Label Proof-of-Concept Trial" @default.
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