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- W2223641502 endingPage "193" @default.
- W2223641502 startingPage "161" @default.
- W2223641502 abstract "B lymphocyte stimulator (BLyS) is a vital B-cell survival and differentiation factor. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). Treatment with BLyS antagonists of mice with established SLE ameliorates disease progression and enhances survival. Moreover, similar treatment of mice with inflammatory arthritis ameliorates the ongoing inflammation and subsequent joint destruction. In humans, BLyS overexpression is common in patients with several systemic immune-based rheumatic diseases (SIRDs), including SLE, rheumatoid arthritis (RA), SS, scleroderma, dermatomyositis, ANCA-associated vasculitis, and mixed cryoglobulinemia. Phase-I and phase-II clinical trials with BLyS antagonists in SLE and RA have documented in vivo biological activities along with favorable safety profiles for these agents and have pointed to beneficial effects in subsets of patients. These features collectively point to BLyS as an attractive therapeutic target in human SIRDs." @default.
- W2223641502 created "2016-06-24" @default.
- W2223641502 creator A5019245481 @default.
- W2223641502 date "2009-01-01" @default.
- W2223641502 modified "2023-09-23" @default.
- W2223641502 title "Systemic Immune-Based Rheumatic Diseases: Blissless States of BLySfulness" @default.
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