Matches in SemOpenAlex for { <https://semopenalex.org/work/W2223845905> ?p ?o ?g. }
- W2223845905 endingPage "1701" @default.
- W2223845905 startingPage "1691" @default.
- W2223845905 abstract "The clinical efficacy of anthracyclines (e.g., doxorubicin and daunorubicin) in cancer therapy is limited by their severe cardiotoxicity, the etiology of which is still not fully understood. The development of anthracycline-induced cardiomyopathy has been found to correlate with myocardial formation and accumulation of anthracycline secondary alcohol metabolites (e.g., doxorubicinol and daunorubicinol) that are produced by distinct cytosolic NADPH-dependent reductases. The aim of the current study is to identify chemical compounds capable of inhibiting myocardial reductases implied in anthracycline reductive metabolism in an attempt to decrease the production of cardiotoxic C-13 alcohol metabolites. Among the variety of tested compounds (metal chelators, radical scavengers, antioxidants, β-blockers, nitrone spin traps, and lipid-lowering drugs), ebselen, cyclopentenone prostaglandins, nitric oxide donors, and short-chain coenzyme Q analogs resulted in being effective inhibitors of both doxorubicinol and daunorubicinol formation. In particular, ebselen (as well as ebselen diselenide, its storage form in the cells) was the most potent inhibitor of cardiotoxic anthracycline alcohol metabolites with 50% inhibition of doxorubicinol formation at 0.2 mol Eq of ebselen with respect to doxorubicin concentration. The high efficacy, together with its favorable pharmacological profile (low toxicity, lack of adverse effects, and metabolic stability) portends ebselen as a promising cardioprotective agent against anthracycline-induced cardiotoxicity." @default.
- W2223845905 created "2016-06-24" @default.
- W2223845905 creator A5011644516 @default.
- W2223845905 creator A5015405335 @default.
- W2223845905 creator A5021881282 @default.
- W2223845905 creator A5072195749 @default.
- W2223845905 creator A5082093327 @default.
- W2223845905 date "2015-08-11" @default.
- W2223845905 modified "2023-10-18" @default.
- W2223845905 title "Inhibition of Anthracycline Alcohol Metabolite Formation in Human Heart Cytosol: A Potential Role for Several Promising Drugs" @default.
- W2223845905 cites W1529138389 @default.
- W2223845905 cites W1560877971 @default.
- W2223845905 cites W1812573520 @default.
- W2223845905 cites W1964382778 @default.
- W2223845905 cites W1965476204 @default.
- W2223845905 cites W1967660686 @default.
- W2223845905 cites W1969916539 @default.
- W2223845905 cites W1973393664 @default.
- W2223845905 cites W1982176508 @default.
- W2223845905 cites W1982839590 @default.
- W2223845905 cites W1984101371 @default.
- W2223845905 cites W1984135972 @default.
- W2223845905 cites W1985856395 @default.
- W2223845905 cites W1987277496 @default.
- W2223845905 cites W1990197810 @default.
- W2223845905 cites W1996399654 @default.
- W2223845905 cites W1997684031 @default.
- W2223845905 cites W2003616925 @default.
- W2223845905 cites W2005244844 @default.
- W2223845905 cites W2009659071 @default.
- W2223845905 cites W2010027282 @default.
- W2223845905 cites W2019008376 @default.
- W2223845905 cites W2023922174 @default.
- W2223845905 cites W2029852623 @default.
- W2223845905 cites W2031720729 @default.
- W2223845905 cites W2032039966 @default.
- W2223845905 cites W2034702811 @default.
- W2223845905 cites W2035925726 @default.
- W2223845905 cites W2040620829 @default.
- W2223845905 cites W2042700527 @default.
- W2223845905 cites W2043779710 @default.
- W2223845905 cites W2049893169 @default.
- W2223845905 cites W2057694313 @default.
- W2223845905 cites W2060205253 @default.
- W2223845905 cites W2061828686 @default.
- W2223845905 cites W2062166266 @default.
- W2223845905 cites W2072140679 @default.
- W2223845905 cites W2078418950 @default.
- W2223845905 cites W2079544758 @default.
- W2223845905 cites W2080304693 @default.
- W2223845905 cites W2081041878 @default.
- W2223845905 cites W2083882252 @default.
- W2223845905 cites W2084304742 @default.
- W2223845905 cites W2086505212 @default.
- W2223845905 cites W2093917686 @default.
- W2223845905 cites W2095405979 @default.
- W2223845905 cites W2098151244 @default.
- W2223845905 cites W2100228429 @default.
- W2223845905 cites W2105461258 @default.
- W2223845905 cites W2106926141 @default.
- W2223845905 cites W2114077740 @default.
- W2223845905 cites W2119544587 @default.
- W2223845905 cites W2121789326 @default.
- W2223845905 cites W2122815214 @default.
- W2223845905 cites W2124873942 @default.
- W2223845905 cites W2126332858 @default.
- W2223845905 cites W2131863929 @default.
- W2223845905 cites W2135319921 @default.
- W2223845905 cites W2138105710 @default.
- W2223845905 cites W2138393164 @default.
- W2223845905 cites W2143167988 @default.
- W2223845905 cites W2147809056 @default.
- W2223845905 cites W2149588634 @default.
- W2223845905 cites W2150475243 @default.
- W2223845905 cites W2150992670 @default.
- W2223845905 cites W2152868870 @default.
- W2223845905 cites W2164159671 @default.
- W2223845905 cites W2169456218 @default.
- W2223845905 cites W4240520654 @default.
- W2223845905 cites W4240547410 @default.
- W2223845905 cites W4240789623 @default.
- W2223845905 cites W4242739944 @default.
- W2223845905 cites W4254717761 @default.
- W2223845905 cites W4362204104 @default.
- W2223845905 doi "https://doi.org/10.1124/dmd.115.065110" @default.
- W2223845905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26265744" @default.
- W2223845905 hasPublicationYear "2015" @default.
- W2223845905 type Work @default.
- W2223845905 sameAs 2223845905 @default.
- W2223845905 citedByCount "8" @default.
- W2223845905 countsByYear W22238459052017 @default.
- W2223845905 countsByYear W22238459052019 @default.
- W2223845905 countsByYear W22238459052020 @default.
- W2223845905 countsByYear W22238459052021 @default.
- W2223845905 crossrefType "journal-article" @default.
- W2223845905 hasAuthorship W2223845905A5011644516 @default.
- W2223845905 hasAuthorship W2223845905A5015405335 @default.
- W2223845905 hasAuthorship W2223845905A5021881282 @default.