FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2223921172> ?p ?o ?g. }

• W2223921172 endingPage "e0004325" @default.
• W2223921172 startingPage "e0004325" @default.
• W2223921172 abstract "Snake envenoming is a significant public health problem in underdeveloped and developing countries. In sub-Saharan Africa, it is estimated that 90,000-400,000 envenomations occur each year, resulting in 3,500-32,000 deaths. Envenomings are caused by snakes from the Viperidae (Bitis spp. and Echis spp.) and Elapidae (Naja spp. and Dendroaspis spp.) families. The African continent has been suffering from a severe antivenom crisis and current antivenom production is only sufficient to treat 25% of snakebite cases. Our aim is to develop high-quality antivenoms against the main snake species found in Mozambique.Adult horses primed with the indicated venoms were divided into 5 groups (B. arietans; B. nasicornis + B. rhinoceros; N. melanoleuca; N. mossambica; N. annulifera + D. polylepis + D. angusticeps) and reimmunized two times for antivenom production. Blood was collected, and plasma was separated and subjected to antibody purification using caprylic acid. Plasmas and antivenoms were subject to titration, affinity determination, cross-recognition assays and in vivo venom lethality neutralization. A commercial anti-Crotalic antivenom was used for comparison.The purified antivenoms exhibited high titers against B. arietans, B. nasicornis and B. rhinoceros (5.18 x 106, 3.60 x 106 and 3.50 x 106 U-E/mL, respectively) and N. melanoleuca, N. mossambica and N. annulifera (7.41 x 106, 3.07 x 106 and 2.60 x 106 U-E/mL, respectively), but lower titers against the D. angusticeps and D. polylepis (1.87 x 106 and 1.67 x 106 U-E/mL). All the groups, except anti-N. melanoleuca, showed significant differences from the anti-Crotalic antivenom (7.55 x 106 U-E/mL). The affinity index of all the groups was high, ranging from 31% to 45%. Cross-recognition assays showed the recognition of proteins with similar molecular weight in the venoms and may indicate the possibility of paraspecific neutralization. The three monospecific antivenoms were able to provide in vivo protection.Our results indicate that the anti-Bitis and anti-Naja antivenoms developed would be useful for treating snakebite envenomations in Mozambique, although their effectiveness should to be increased. We propose instead the development of monospecific antivenoms, which would serve as the basis for two polyvalent antivenoms, the anti-Bitis and anti-Elapidae. Polyvalent antivenoms represent an increase in treatment quality, as they have a wider range of application and are easier to distribute and administer to snake envenoming victims." @default.
• W2223921172 created "2016-06-24" @default.
• W2223921172 creator A5038911096 @default.
• W2223921172 creator A5057677030 @default.
• W2223921172 creator A5079383826 @default.
• W2223921172 creator A5082415610 @default.
• W2223921172 date "2016-01-05" @default.
• W2223921172 modified "2023-10-02" @default.
• W2223921172 title "Development of Equine IgG Antivenoms against Major Snake Groups in Mozambique" @default.
• W2223921172 cites W1966756198 @default.
• W2223921172 cites W1979559936 @default.
• W2223921172 cites W1979649545 @default.
• W2223921172 cites W1986088238 @default.
• W2223921172 cites W1997160334 @default.
• W2223921172 cites W2005616283 @default.
• W2223921172 cites W2013622729 @default.
• W2223921172 cites W2018289835 @default.
• W2223921172 cites W2037559592 @default.
• W2223921172 cites W2038763988 @default.
• W2223921172 cites W2042793563 @default.
• W2223921172 cites W2046081363 @default.
• W2223921172 cites W2055170446 @default.
• W2223921172 cites W2056986360 @default.
• W2223921172 cites W2060639023 @default.
• W2223921172 cites W2061491954 @default.
• W2223921172 cites W2065923963 @default.
• W2223921172 cites W2068039697 @default.
• W2223921172 cites W2075969569 @default.
• W2223921172 cites W2084750170 @default.
• W2223921172 cites W2087227243 @default.
• W2223921172 cites W2100837269 @default.
• W2223921172 cites W2101108802 @default.
• W2223921172 cites W2102553969 @default.
• W2223921172 cites W2109032445 @default.
• W2223921172 cites W2117250036 @default.
• W2223921172 cites W2134743392 @default.
• W2223921172 cites W2161969523 @default.
• W2223921172 cites W2417578947 @default.
• W2223921172 cites W4232534952 @default.
• W2223921172 doi "https://doi.org/10.1371/journal.pntd.0004325" @default.
• W2223921172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4701360" @default.
• W2223921172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26730709" @default.
• W2223921172 hasPublicationYear "2016" @default.
• W2223921172 type Work @default.
• W2223921172 sameAs 2223921172 @default.
• W2223921172 citedByCount "18" @default.
• W2223921172 countsByYear W22239211722017 @default.
• W2223921172 countsByYear W22239211722018 @default.
• W2223921172 countsByYear W22239211722019 @default.
• W2223921172 countsByYear W22239211722020 @default.
• W2223921172 countsByYear W22239211722021 @default.
• W2223921172 countsByYear W22239211722022 @default.
• W2223921172 countsByYear W22239211722023 @default.
• W2223921172 crossrefType "journal-article" @default.
• W2223921172 hasAuthorship W2223921172A5038911096 @default.
• W2223921172 hasAuthorship W2223921172A5057677030 @default.
• W2223921172 hasAuthorship W2223921172A5079383826 @default.
• W2223921172 hasAuthorship W2223921172A5082415610 @default.
• W2223921172 hasBestOaLocation W22239211721 @default.
• W2223921172 hasConcept C117287731 @default.
• W2223921172 hasConcept C145600735 @default.
• W2223921172 hasConcept C18903297 @default.
• W2223921172 hasConcept C2776725428 @default.
• W2223921172 hasConcept C2777009914 @default.
• W2223921172 hasConcept C2777591057 @default.
• W2223921172 hasConcept C2779231127 @default.
• W2223921172 hasConcept C2779448229 @default.
• W2223921172 hasConcept C42972112 @default.
• W2223921172 hasConcept C556039675 @default.
• W2223921172 hasConcept C71924100 @default.
• W2223921172 hasConcept C86803240 @default.
• W2223921172 hasConcept C90856448 @default.
• W2223921172 hasConceptScore W2223921172C117287731 @default.
• W2223921172 hasConceptScore W2223921172C145600735 @default.
• W2223921172 hasConceptScore W2223921172C18903297 @default.
• W2223921172 hasConceptScore W2223921172C2776725428 @default.
• W2223921172 hasConceptScore W2223921172C2777009914 @default.
• W2223921172 hasConceptScore W2223921172C2777591057 @default.
• W2223921172 hasConceptScore W2223921172C2779231127 @default.
• W2223921172 hasConceptScore W2223921172C2779448229 @default.
• W2223921172 hasConceptScore W2223921172C42972112 @default.
• W2223921172 hasConceptScore W2223921172C556039675 @default.
• W2223921172 hasConceptScore W2223921172C71924100 @default.
• W2223921172 hasConceptScore W2223921172C86803240 @default.
• W2223921172 hasConceptScore W2223921172C90856448 @default.
• W2223921172 hasIssue "1" @default.
• W2223921172 hasLocation W22239211721 @default.
• W2223921172 hasLocation W22239211722 @default.
• W2223921172 hasLocation W22239211723 @default.
• W2223921172 hasLocation W22239211724 @default.
• W2223921172 hasOpenAccess W2223921172 @default.
• W2223921172 hasPrimaryLocation W22239211721 @default.
• W2223921172 hasRelatedWork W1977027334 @default.
• W2223921172 hasRelatedWork W1985492465 @default.
• W2223921172 hasRelatedWork W2016549069 @default.
• W2223921172 hasRelatedWork W2039852604 @default.
• W2223921172 hasRelatedWork W2187266569 @default.
• W2223921172 hasRelatedWork W2773445094 @default.

• next