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- W2224005114 abstract "Adaptive enrichment designs involve rules for restricting enrollment to a subset of the population during the course of an ongoing trial. This can be used to target those who benefit from the experimental treatment. To leverage prognostic information in baseline variables and short-term outcomes, we use a semiparametric, locally efficient estimator. We assess, through simulation studies, how different design parameters affect performance in terms of precision, power, sample size, and trial duration. Our simulation distributions mimic features of data from the Alzheimer’s Disease ∗Corresponding author email address: tqian2@jhu.edu" @default.
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- W2224005114 date "2015-01-01" @default.
- W2224005114 modified "2023-09-27" @default.
- W2224005114 title "IMPACT OF DELAYED OUTCOMES, ACCURUAL RATES, AND PROGNOSTIC VARIABLES ON A SIMULATED RANDOMIZED TRIAL WITH ADAPTIVE ENRICHMENT" @default.
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