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- W2224005909 abstract "Statins' therapy in osteoporosis can aggravate muscle damage. This study was designed to assess which agent, L-carnitine or coenzyme Q10, could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats.Forty-eight female Sprague Dawley rats were used; forty rats were ovariectomized while eight were sham-operated. Eight weeks post-ovariectomy, rats were divided into ovariectomized-untreated group and four ovariectomized-treated groups (n=8) which received by gavage (mg/(kg∙d), for 8 weeks) 17β-estradiol (0.1), atorvastatin (50), atorvastatin (50)+L-carnitine (100), or atorvastatin (50)+coenzyme Q10 (20). At the end of therapy, bone mineral density (BMD), bone mineral content (BMC), and serum levels of bone metabolic markers (BMMs) and creatine kinase (CK) were measured. Femurs were used for studying the breaking strength and histopathological changes.Treatment with atorvastatin+L-carnitine restored BMD, BMC, and bone strength to near normal levels. Estrogen therapy restored BMD and BMC to near normal levels, but failed to increase bone strength. Although atorvastatin and atorvastatin+coenzyme Q10 improved BMD, BMC, and bone strength, they failed to restore levels to normal. All treatments decreased BMMs and improved histopathological changes maximally with atorvastatin+L-carnitine which restored levels to near normal. Atorvastatin aggravated the ovariectomy-induced increase in CK level while estrogen, atorvastatin+L-carnitine, and atorvastatin+coenzyme Q10 decreased its level mainly with atorvastatin+L-carnitine which restored the level to near normal.Co-administration of L-carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats. This could be valuable in treatment of osteoporotic patients. However, further confirmatory studies are needed." @default.
- W2224005909 created "2016-06-24" @default.
- W2224005909 creator A5019773537 @default.
- W2224005909 date "2016-01-01" @default.
- W2224005909 modified "2023-10-12" @default.
- W2224005909 title "l-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats" @default.
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- W2224005909 cites W144643052 @default.
- W2224005909 cites W1502673885 @default.
- W2224005909 cites W1527630710 @default.
- W2224005909 cites W1553141569 @default.
- W2224005909 cites W165604035 @default.
- W2224005909 cites W192661046 @default.
- W2224005909 cites W1958186397 @default.
- W2224005909 cites W1965249188 @default.
- W2224005909 cites W1966046783 @default.
- W2224005909 cites W1967522907 @default.
- W2224005909 cites W1971713640 @default.
- W2224005909 cites W1973758673 @default.
- W2224005909 cites W1975593610 @default.
- W2224005909 cites W1984736619 @default.
- W2224005909 cites W1985595789 @default.
- W2224005909 cites W1988963428 @default.
- W2224005909 cites W1991817712 @default.
- W2224005909 cites W1993983990 @default.
- W2224005909 cites W1998719302 @default.
- W2224005909 cites W2000584674 @default.
- W2224005909 cites W2000656455 @default.
- W2224005909 cites W2001241660 @default.
- W2224005909 cites W2002499246 @default.
- W2224005909 cites W2004722801 @default.
- W2224005909 cites W2005188582 @default.
- W2224005909 cites W2006366716 @default.
- W2224005909 cites W2010255900 @default.
- W2224005909 cites W2015242880 @default.
- W2224005909 cites W2017157616 @default.
- W2224005909 cites W2020571751 @default.
- W2224005909 cites W2023255055 @default.
- W2224005909 cites W2026553955 @default.
- W2224005909 cites W2026670401 @default.
- W2224005909 cites W2034131055 @default.
- W2224005909 cites W2044147730 @default.
- W2224005909 cites W2045798461 @default.
- W2224005909 cites W2053633976 @default.
- W2224005909 cites W2054050229 @default.
- W2224005909 cites W2054396894 @default.
- W2224005909 cites W2059541412 @default.
- W2224005909 cites W2061300570 @default.
- W2224005909 cites W2065885452 @default.
- W2224005909 cites W2070063868 @default.
- W2224005909 cites W2070383923 @default.
- W2224005909 cites W2078439819 @default.
- W2224005909 cites W2079511649 @default.
- W2224005909 cites W2085905912 @default.
- W2224005909 cites W2087451614 @default.
- W2224005909 cites W2089611661 @default.
- W2224005909 cites W2089847783 @default.
- W2224005909 cites W2097695029 @default.
- W2224005909 cites W2103357839 @default.
- W2224005909 cites W2109828316 @default.
- W2224005909 cites W2110828193 @default.
- W2224005909 cites W2123338974 @default.
- W2224005909 cites W2132514807 @default.
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- W2224005909 doi "https://doi.org/10.1631/jzus.b1500065" @default.
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