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• W2224159390 abstract "Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects of non-competitive NMDA-antagonist stimulants such as dizocilpine (MK-801) and phencyclidine (PCP). This study explores the role of the inducible nitric oxide synthase inhibitors (iNOS) aminoguanidine (AG) and (-)-epigallocatechin-3-gallate (EGCG) in NMDA-antagonist induced motoric behavior and prefrontal cortical glutamate efflux. Adult male rats were administered a dose range of AG, EGCG, or vehicle prior to receiving NMDA antagonists MK-801, PCP, or a conventional psychostimulant (cocaine) and tested for motoric behavior in an open arena. Glutamate in the medial prefrontal cortex (mPFC) was measured using in vivo microdialysis after a combination of AG or EGCG prior to MK-801. Acute administration of AG or EGCG dose-dependently attenuated the locomotor and ataxic properties of MK-801 and PCP. Both AG and EGCG were unable to block the motoric effects of cocaine, indicating the acute pharmacologic action of AG and EGCG is specific to NMDA antagonism and not generalizable to all stimulant class drugs. AG and EGCG normalized MK-801-stimulated mPFC glutamate efflux. These data demonstrate that AG and EGCG attenuates NMDA antagonist-stimulated motoric behavior and cortical glutamate efflux. Our results suggest that EGCG-like polyphenol nutraceuticals (contained in green tea and chocolate) may be clinically useful in protecting against the adverse behavioral dissociative and cortical glutamate stimulating effects of NMDA antagonists. Medications that interfere with NMDA antagonists such as MK-801 and PCP have been proposed as treatments for schizophrenia." @default.
• W2224159390 created "2016-06-24" @default.
• W2224159390 creator A5039795787 @default.
• W2224159390 creator A5048398417 @default.
• W2224159390 creator A5090394722 @default.
• W2224159390 date "2015-12-15" @default.
• W2224159390 modified "2023-09-27" @default.
• W2224159390 title "Inducible Nitric Oxide Inhibitors Block NMDA Antagonist-Stimulated Motoric Behaviors and Medial Prefrontal Cortical Glutamate Efflux" @default.
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• W2224159390 cites W145031886 @default.
• W2224159390 cites W1569637190 @default.
• W2224159390 cites W1729010372 @default.
• W2224159390 cites W1842976670 @default.
• W2224159390 cites W1844257758 @default.
• W2224159390 cites W1914381346 @default.
• W2224159390 cites W1964811607 @default.
• W2224159390 cites W1965838484 @default.
• W2224159390 cites W1968820755 @default.
• W2224159390 cites W1970196749 @default.
• W2224159390 cites W1970580463 @default.
• W2224159390 cites W1974850067 @default.
• W2224159390 cites W1975679961 @default.
• W2224159390 cites W1981023844 @default.
• W2224159390 cites W1984733445 @default.
• W2224159390 cites W1986336245 @default.
• W2224159390 cites W1994009282 @default.
• W2224159390 cites W1994300892 @default.
• W2224159390 cites W1994386458 @default.
• W2224159390 cites W1994430859 @default.
• W2224159390 cites W1997198720 @default.
• W2224159390 cites W1998296450 @default.
• W2224159390 cites W1998429087 @default.
• W2224159390 cites W1999108312 @default.
• W2224159390 cites W2005141090 @default.
• W2224159390 cites W2009798253 @default.
• W2224159390 cites W2011928284 @default.
• W2224159390 cites W2013436204 @default.
• W2224159390 cites W2016965652 @default.
• W2224159390 cites W2019425955 @default.
• W2224159390 cites W2019442403 @default.
• W2224159390 cites W2021099633 @default.
• W2224159390 cites W2021569136 @default.
• W2224159390 cites W2022495097 @default.
• W2224159390 cites W2023163434 @default.
• W2224159390 cites W2026577163 @default.
• W2224159390 cites W2027517558 @default.
• W2224159390 cites W2029803348 @default.
• W2224159390 cites W2031496747 @default.
• W2224159390 cites W2045339715 @default.
• W2224159390 cites W2046606445 @default.
• W2224159390 cites W2049661031 @default.
• W2224159390 cites W2051685982 @default.
• W2224159390 cites W2052380265 @default.
• W2224159390 cites W2056188596 @default.
• W2224159390 cites W2056666175 @default.
• W2224159390 cites W2060599083 @default.
• W2224159390 cites W2061506085 @default.
• W2224159390 cites W2067335226 @default.
• W2224159390 cites W2068781017 @default.
• W2224159390 cites W2069886477 @default.
• W2224159390 cites W2074462624 @default.
• W2224159390 cites W2075068003 @default.
• W2224159390 cites W2077890224 @default.
• W2224159390 cites W2080248624 @default.
• W2224159390 cites W2082429191 @default.
• W2224159390 cites W2084299214 @default.
• W2224159390 cites W2084672945 @default.
• W2224159390 cites W2086425346 @default.
• W2224159390 cites W2089925765 @default.
• W2224159390 cites W2090266455 @default.
• W2224159390 cites W2090703365 @default.
• W2224159390 cites W2093019685 @default.
• W2224159390 cites W2096198839 @default.
• W2224159390 cites W2097820520 @default.
• W2224159390 cites W2103903531 @default.
• W2224159390 cites W2108040321 @default.
• W2224159390 cites W2113407333 @default.
• W2224159390 cites W2122067329 @default.
• W2224159390 cites W2122965328 @default.
• W2224159390 cites W2132562527 @default.
• W2224159390 cites W2147243027 @default.
• W2224159390 cites W2156427665 @default.
• W2224159390 cites W2158137297 @default.
• W2224159390 cites W2261115509 @default.
• W2224159390 cites W4249936317 @default.
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• W2224159390 doi "https://doi.org/10.3389/fphar.2015.00292" @default.
• W2224159390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4678197" @default.
• W2224159390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26696891" @default.
• W2224159390 hasPublicationYear "2015" @default.
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