Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224197312> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2224197312 endingPage "248" @default.
- W2224197312 startingPage "248" @default.
- W2224197312 abstract "Background Inhibitory antibodies to factor VIII (FVIII) are an important complication when managing patients with hemophilia A. Immune tolerance induction (ITI) has been regarded as a useful method for eradicating inhibitors. We report the results of a retrospective study in Korean patients with hemophilia A who underwent ITI. Methods We reviewed the records of patients with hemophilia A with inhibitors who underwent ITI from March 2004 to December 2014. ITI was started with FVIII concentrates at 100 IU/kg, 3 times per week. The dose of FVIII was reduced according to the inhibitor titer and recovery of FVIII. Inhibitor elimination was defined as the time taken to achieve a negative inhibitor assay with no anamnestic response and normal FVIII recovery and/or normal half-life. Results In total, 17 patients with severe hemophilia A were evaluated. Complete tolerance was achieved in 14 of 17 patients (83%). The mean peak inhibitor titer before ITI was 38.4 BU/mL. The mean treatment duration was 26.2 months. The mean duration between inhibitor detection and ITI was 5.1 years in the complete tolerance group and 10.8 years in the partial tolerance and failed group. Conclusion This study shows that ITI can be an effective and well-tolerated method for eradicating inhibitors. Possible influencing factors for ITI success were age at the start of ITI treatment and duration after inhibitor detection. More research to provide further insight about other factors and conditions is needed." @default.
- W2224197312 created "2016-06-24" @default.
- W2224197312 creator A5024197099 @default.
- W2224197312 creator A5052928892 @default.
- W2224197312 creator A5061045547 @default.
- W2224197312 creator A5061506772 @default.
- W2224197312 creator A5083674170 @default.
- W2224197312 date "2015-01-01" @default.
- W2224197312 modified "2023-10-14" @default.
- W2224197312 title "Immune tolerance induction in patients with severe hemophilia A with inhibitors" @default.
- W2224197312 cites W1537488882 @default.
- W2224197312 cites W1545229991 @default.
- W2224197312 cites W1921219324 @default.
- W2224197312 cites W1940794074 @default.
- W2224197312 cites W1990868039 @default.
- W2224197312 cites W1998614164 @default.
- W2224197312 cites W2041148634 @default.
- W2224197312 cites W2072864431 @default.
- W2224197312 cites W2076953709 @default.
- W2224197312 cites W2080558518 @default.
- W2224197312 cites W2103667265 @default.
- W2224197312 cites W2123308764 @default.
- W2224197312 cites W2124289565 @default.
- W2224197312 cites W2126463715 @default.
- W2224197312 cites W2143179249 @default.
- W2224197312 cites W2148267426 @default.
- W2224197312 cites W2149508805 @default.
- W2224197312 cites W2158500407 @default.
- W2224197312 cites W2166067588 @default.
- W2224197312 cites W2177406717 @default.
- W2224197312 cites W2417605240 @default.
- W2224197312 cites W2419572270 @default.
- W2224197312 cites W4292576288 @default.
- W2224197312 doi "https://doi.org/10.5045/br.2015.50.4.248" @default.
- W2224197312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4705051" @default.
- W2224197312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26770953" @default.
- W2224197312 hasPublicationYear "2015" @default.
- W2224197312 type Work @default.
- W2224197312 sameAs 2224197312 @default.
- W2224197312 citedByCount "6" @default.
- W2224197312 countsByYear W22241973122016 @default.
- W2224197312 countsByYear W22241973122018 @default.
- W2224197312 countsByYear W22241973122020 @default.
- W2224197312 countsByYear W22241973122021 @default.
- W2224197312 countsByYear W22241973122022 @default.
- W2224197312 countsByYear W22241973122023 @default.
- W2224197312 crossrefType "journal-article" @default.
- W2224197312 hasAuthorship W2224197312A5024197099 @default.
- W2224197312 hasAuthorship W2224197312A5052928892 @default.
- W2224197312 hasAuthorship W2224197312A5061045547 @default.
- W2224197312 hasAuthorship W2224197312A5061506772 @default.
- W2224197312 hasAuthorship W2224197312A5083674170 @default.
- W2224197312 hasBestOaLocation W22241973121 @default.
- W2224197312 hasConcept C126322002 @default.
- W2224197312 hasConcept C141071460 @default.
- W2224197312 hasConcept C159654299 @default.
- W2224197312 hasConcept C167135981 @default.
- W2224197312 hasConcept C203014093 @default.
- W2224197312 hasConcept C2777702733 @default.
- W2224197312 hasConcept C32611913 @default.
- W2224197312 hasConcept C71924100 @default.
- W2224197312 hasConcept C81182388 @default.
- W2224197312 hasConcept C8891405 @default.
- W2224197312 hasConcept C90924648 @default.
- W2224197312 hasConceptScore W2224197312C126322002 @default.
- W2224197312 hasConceptScore W2224197312C141071460 @default.
- W2224197312 hasConceptScore W2224197312C159654299 @default.
- W2224197312 hasConceptScore W2224197312C167135981 @default.
- W2224197312 hasConceptScore W2224197312C203014093 @default.
- W2224197312 hasConceptScore W2224197312C2777702733 @default.
- W2224197312 hasConceptScore W2224197312C32611913 @default.
- W2224197312 hasConceptScore W2224197312C71924100 @default.
- W2224197312 hasConceptScore W2224197312C81182388 @default.
- W2224197312 hasConceptScore W2224197312C8891405 @default.
- W2224197312 hasConceptScore W2224197312C90924648 @default.
- W2224197312 hasIssue "4" @default.
- W2224197312 hasLocation W22241973121 @default.
- W2224197312 hasLocation W22241973122 @default.
- W2224197312 hasLocation W22241973123 @default.
- W2224197312 hasLocation W22241973124 @default.
- W2224197312 hasOpenAccess W2224197312 @default.
- W2224197312 hasPrimaryLocation W22241973121 @default.
- W2224197312 hasRelatedWork W1572283981 @default.
- W2224197312 hasRelatedWork W1974427279 @default.
- W2224197312 hasRelatedWork W2034707118 @default.
- W2224197312 hasRelatedWork W2411114470 @default.
- W2224197312 hasRelatedWork W2417961914 @default.
- W2224197312 hasRelatedWork W2474039552 @default.
- W2224197312 hasRelatedWork W2945124548 @default.
- W2224197312 hasRelatedWork W3048051248 @default.
- W2224197312 hasRelatedWork W4200563690 @default.
- W2224197312 hasRelatedWork W62711790 @default.
- W2224197312 hasVolume "50" @default.
- W2224197312 isParatext "false" @default.
- W2224197312 isRetracted "false" @default.
- W2224197312 magId "2224197312" @default.
- W2224197312 workType "article" @default.