Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224272007> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2224272007 abstract "iii Abstract Diabetes, a persistent endocrine disorder causing high rate of mortality, has been treated with adequate methods for the last hundred years after the discovery of insulin by Banting and Best though its clinical features were first described by the Egyptians 3000 years ago. The effective treatment strategies started to develop when the first oral hypoglycemic drugs, tolbutamide and carbutamide, came into the market. Presently, the establishment of new methods and strategies of combination therapy is considered to be more convenient over monotherapy. The main objective of this current study was to estimate a DPP-4 inhibitor named sitagliptin either alone or in a combination formulation with metformin. The quality of both available single and combination tablets of local companies with the innovator brand were also compared. The method followed for the determination of sitagliptin employed a RP‐HPLC procedure with PDA detector consisting of Luna 5μ C18column (250 mm x 4.60 mm) inserting an injection volume of 10μL and eluted by the mobile phase of 0.02 M potassium dihydrogen phosphate (pH4) and acetonitrile in a ratio of 60:40 respectively, which is pumped at a flow rate of 1.0 mL/min. The method carried out the detection at a wavelength of 252 nm for the binary mixture and of 210 nm for the single sitagliptin; and had the elution time of 3.45 and 2.28 minutes for sitagliptin and metformin respectively. All the values for system suitability parameters were also feasible with this method. The release kinetics profile of sitagliptin was very precise and accurate and can be concluded that this method is suitable for any tablet containing sitagliptin in the routine analysis of quality" @default.
- W2224272007 created "2016-06-24" @default.
- W2224272007 creator A5054998107 @default.
- W2224272007 date "2015-01-01" @default.
- W2224272007 modified "2023-09-26" @default.
- W2224272007 title "Evaluation and comparison of release kinetics of an anti diabetic formulation" @default.
- W2224272007 cites W1498984805 @default.
- W2224272007 cites W1540831188 @default.
- W2224272007 cites W1559269812 @default.
- W2224272007 cites W1585595725 @default.
- W2224272007 cites W1888759561 @default.
- W2224272007 cites W1918334404 @default.
- W2224272007 cites W1976760479 @default.
- W2224272007 cites W2005150035 @default.
- W2224272007 cites W2009480581 @default.
- W2224272007 cites W2016017842 @default.
- W2224272007 cites W2027974633 @default.
- W2224272007 cites W2031484324 @default.
- W2224272007 cites W2037879477 @default.
- W2224272007 cites W2046577336 @default.
- W2224272007 cites W2071345208 @default.
- W2224272007 cites W2074427854 @default.
- W2224272007 cites W2124754873 @default.
- W2224272007 cites W2159087408 @default.
- W2224272007 cites W2160183149 @default.
- W2224272007 cites W2167888541 @default.
- W2224272007 cites W2168137791 @default.
- W2224272007 cites W2182873957 @default.
- W2224272007 cites W2187089281 @default.
- W2224272007 cites W2311603308 @default.
- W2224272007 cites W2323312477 @default.
- W2224272007 cites W2520432709 @default.
- W2224272007 cites W2592643186 @default.
- W2224272007 cites W2609710147 @default.
- W2224272007 cites W81118813 @default.
- W2224272007 cites W851215063 @default.
- W2224272007 cites W2182747356 @default.
- W2224272007 cites W2183898386 @default.
- W2224272007 cites W2183957566 @default.
- W2224272007 cites W2184429403 @default.
- W2224272007 cites W2185558729 @default.
- W2224272007 hasPublicationYear "2015" @default.
- W2224272007 type Work @default.
- W2224272007 sameAs 2224272007 @default.
- W2224272007 citedByCount "0" @default.
- W2224272007 crossrefType "journal-article" @default.
- W2224272007 hasAuthorship W2224272007A5054998107 @default.
- W2224272007 hasConcept C126322002 @default.
- W2224272007 hasConcept C185592680 @default.
- W2224272007 hasConcept C2776054734 @default.
- W2224272007 hasConcept C2779284873 @default.
- W2224272007 hasConcept C2779306644 @default.
- W2224272007 hasConcept C2780323712 @default.
- W2224272007 hasConcept C2910260750 @default.
- W2224272007 hasConcept C43617362 @default.
- W2224272007 hasConcept C71924100 @default.
- W2224272007 hasConcept C98274493 @default.
- W2224272007 hasConceptScore W2224272007C126322002 @default.
- W2224272007 hasConceptScore W2224272007C185592680 @default.
- W2224272007 hasConceptScore W2224272007C2776054734 @default.
- W2224272007 hasConceptScore W2224272007C2779284873 @default.
- W2224272007 hasConceptScore W2224272007C2779306644 @default.
- W2224272007 hasConceptScore W2224272007C2780323712 @default.
- W2224272007 hasConceptScore W2224272007C2910260750 @default.
- W2224272007 hasConceptScore W2224272007C43617362 @default.
- W2224272007 hasConceptScore W2224272007C71924100 @default.
- W2224272007 hasConceptScore W2224272007C98274493 @default.
- W2224272007 hasLocation W22242720071 @default.
- W2224272007 hasOpenAccess W2224272007 @default.
- W2224272007 hasPrimaryLocation W22242720071 @default.
- W2224272007 hasRelatedWork W1427339620 @default.
- W2224272007 hasRelatedWork W1964770583 @default.
- W2224272007 hasRelatedWork W2005150035 @default.
- W2224272007 hasRelatedWork W2077502436 @default.
- W2224272007 hasRelatedWork W2107111353 @default.
- W2224272007 hasRelatedWork W2185012726 @default.
- W2224272007 hasRelatedWork W2186175638 @default.
- W2224272007 hasRelatedWork W2186245699 @default.
- W2224272007 hasRelatedWork W2189028842 @default.
- W2224272007 hasRelatedWork W2791685375 @default.
- W2224272007 hasRelatedWork W2963402064 @default.
- W2224272007 hasRelatedWork W3113267416 @default.
- W2224272007 hasRelatedWork W3119820462 @default.
- W2224272007 hasRelatedWork W3195919972 @default.
- W2224272007 hasRelatedWork W2182747356 @default.
- W2224272007 hasRelatedWork W2183898386 @default.
- W2224272007 hasRelatedWork W2183957566 @default.
- W2224272007 hasRelatedWork W2184429403 @default.
- W2224272007 hasRelatedWork W2189455498 @default.
- W2224272007 hasRelatedWork W2577146878 @default.
- W2224272007 isParatext "false" @default.
- W2224272007 isRetracted "false" @default.
- W2224272007 magId "2224272007" @default.
- W2224272007 workType "article" @default.