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- W2224462904 abstract "Objective. To evaluated effect of adalimumab treatment on activity of arthritis, enthesitis, psoriasis and functional status in PsA patients (pts).Subjects and methods. 18 pts with active PsA (12 female, 6 male), median age 43,1±10,2 years (yrs) (range 24-56), median duration ofpsoriasis 16,7±9,6 yrs (range 4-33), median duration of PsA 9,2±6,7 yrs (range 1,5-23) received Adalimumab 40 mg subcutaneouslyevery other week (wk) for 12 wks in open-label study. Evaluations of treatment effects were conducted by the PSARC, ACR 20, 50 and 70,LEI, PASI, BSA, HAQ and CRP at wks 4 and 12.Results. The sings of activity of PsA at baseline were: DAS=4,8 (4,0; 5,45), LEI=4,25 (0,25; 8,05), PASI=10,5 (7,2; 12,1), BSA=1,75(1; 2), HAQ=1,125 (0,875; 1,5), СRР=27,9 (11,4; 34,6). After 4 wks all parameters significantly improved: DAS=2,85 (2,1; 3,1),LEI=1,86 (0; 3,97), PASI=6,4 (2,8; 8), BSA=0,75 (0,15; 1), HAQ=0,375 (0,125; 0,625), СRP=1,7 (1,4; 3,2) and were maintainedafter 12 wks: DAS=1,6 (1,3; 2,03), LEI=0,38 (0; 0,89), PASI=1,1 (0,4; 2,2), BSA=0 (0; 0,9), HAQ=0,312 (0; 0,625), СRР=1,75 (0,7;3,6); p<0,05. 100% pts achieved PSARC at the 4 and 12 wks 55,6; 11,1 and 27,8% PsA pts achieved ACR 20, 50 and 70 at 4 wks and11,1; 33,3 and 55,6% at 12 wks respectively. Adalimumab was well tolerated throughout the study.Conclusion. Adalimumab therapy significantly reduced the main clinical symptoms of PsA: arthritis, enthesitis, psoriasis. Additionally itimproved quality of life PsA patients and was well tolerated." @default.
- W2224462904 created "2016-06-24" @default.
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- W2224462904 date "2010-06-15" @default.
- W2224462904 modified "2023-09-26" @default.
- W2224462904 title "THE FIRST RUSSIAN EXPERIENCE OF ADALIMUMAB TREATMENT IN PSORIATIC ARTHRITIS" @default.
- W2224462904 doi "https://doi.org/10.14412/1995-4484-2010-448" @default.
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