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- W2224507029 endingPage "250" @default.
- W2224507029 startingPage "221" @default.
- W2224507029 abstract "Huntington’s disease (HD), Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders associated with aging. The main hallmarks of these pathologies are deposits of mutant proteins, mitochondrial dysfunctions, reactive oxygen species (ROS) and neuronal death. These diseases affect from heterogeneous form to different brain regions. In fact, psychophysical, electrophysiological and morphological evidence shows that retinal and higher visual centers disturbances occur in HD, PD and AD. Thus, patients with these disorders suffer contrast sensitivity deficits, altered color vision and damaged conscious and unconscious visual perception. These visual deficiencies may contribute to symptoms of these pathologies related to behavior, memory and difficulty in performing daily tasks such as driving, reading or keeping their balance. This chapter tries to integrate the visual changes in pathogenesis and symptomatology of patients with HD, PD and AD and reviews the recent findings in animal models of these diseases to provide an insight into how retinal changes might contribute to symptoms of HD, PD and AD." @default.
- W2224507029 created "2016-06-24" @default.
- W2224507029 creator A5007059014 @default.
- W2224507029 creator A5057203967 @default.
- W2224507029 creator A5066300216 @default.
- W2224507029 date "2011-01-01" @default.
- W2224507029 modified "2023-09-25" @default.
- W2224507029 title "Retinal Disturbances in Patients and Animal Models with Huntington’s, Parkinson’s and Alzheimer’s Disease" @default.
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