Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224668502> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2224668502 endingPage "306" @default.
- W2224668502 startingPage "300" @default.
- W2224668502 abstract "Aim To investigate the effect of berberine on damaged morphology and glucolipid metabolization in skeletal muscle of diabetic rat and the relationship between peroxisome proliferator-activated receptor(PPARs) ɑ/γ/δ protein expression.Methods Type 2 diabetes mellitus rats were induced by an injection of 35 mg·kg-1 streptozotocin(STZ)and a high-carbohydrate/high-fat diet for 16 weeks.From week 17 to 32,diabetic rats were given low-,middle-,high-dose berberine(75,150,300 mg·kg-1),fenofibrate(100 mg·kg-1) and rosiglitazone(4 mg·kg-1) by oral administration,respectively.The skeletal muscle structure was observed with hematoxylin-eosin (HE) staining,glycogen and triglyceride contents were measured by spectrophotometry and PPAR ɑ/γ/δ protein expressions were detected bv immanohistochemistry.Results Fiber distribution remained normal in skeletal muscles of all the groups,middle-,high-dose berberine partly improved diabetic fibre atrophy,increased glycogen and decreasedtriglyceride levels in diabetic musele(P＜0.01).Middle-,high-dose berberine and rosiglitazone all significantly reduced PPARγprotein level in diabetic skeletal muscle (P＜0.01):middle-,high-dose berberine and fenofibrate strikingly increased both PPARɑ and PPAR6 expression(P＜0.01).Conclusion Berberine modulates PPAR ɑ/γ/δ protein expression in diabetic skeletal muscle which may contribute to ameliorate fibre damage and glucolipid metabolization." @default.
- W2224668502 created "2016-06-24" @default.
- W2224668502 creator A5013047769 @default.
- W2224668502 creator A5047526193 @default.
- W2224668502 date "2007-01-01" @default.
- W2224668502 modified "2023-09-27" @default.
- W2224668502 title "Effect of berberine on glucolipid metabolization in diabetic skeletal muscle and its mechanism" @default.
- W2224668502 hasPublicationYear "2007" @default.
- W2224668502 type Work @default.
- W2224668502 sameAs 2224668502 @default.
- W2224668502 citedByCount "0" @default.
- W2224668502 crossrefType "journal-article" @default.
- W2224668502 hasAuthorship W2224668502A5013047769 @default.
- W2224668502 hasAuthorship W2224668502A5047526193 @default.
- W2224668502 hasConcept C126322002 @default.
- W2224668502 hasConcept C127078168 @default.
- W2224668502 hasConcept C134018914 @default.
- W2224668502 hasConcept C170493617 @default.
- W2224668502 hasConcept C185592680 @default.
- W2224668502 hasConcept C187345961 @default.
- W2224668502 hasConcept C2777180221 @default.
- W2224668502 hasConcept C2777499176 @default.
- W2224668502 hasConcept C2778110834 @default.
- W2224668502 hasConcept C2778163477 @default.
- W2224668502 hasConcept C2778913445 @default.
- W2224668502 hasConcept C2779280383 @default.
- W2224668502 hasConcept C2779959927 @default.
- W2224668502 hasConcept C2780116568 @default.
- W2224668502 hasConcept C2780152017 @default.
- W2224668502 hasConcept C55493867 @default.
- W2224668502 hasConcept C555293320 @default.
- W2224668502 hasConcept C71924100 @default.
- W2224668502 hasConceptScore W2224668502C126322002 @default.
- W2224668502 hasConceptScore W2224668502C127078168 @default.
- W2224668502 hasConceptScore W2224668502C134018914 @default.
- W2224668502 hasConceptScore W2224668502C170493617 @default.
- W2224668502 hasConceptScore W2224668502C185592680 @default.
- W2224668502 hasConceptScore W2224668502C187345961 @default.
- W2224668502 hasConceptScore W2224668502C2777180221 @default.
- W2224668502 hasConceptScore W2224668502C2777499176 @default.
- W2224668502 hasConceptScore W2224668502C2778110834 @default.
- W2224668502 hasConceptScore W2224668502C2778163477 @default.
- W2224668502 hasConceptScore W2224668502C2778913445 @default.
- W2224668502 hasConceptScore W2224668502C2779280383 @default.
- W2224668502 hasConceptScore W2224668502C2779959927 @default.
- W2224668502 hasConceptScore W2224668502C2780116568 @default.
- W2224668502 hasConceptScore W2224668502C2780152017 @default.
- W2224668502 hasConceptScore W2224668502C55493867 @default.
- W2224668502 hasConceptScore W2224668502C555293320 @default.
- W2224668502 hasConceptScore W2224668502C71924100 @default.
- W2224668502 hasIssue "4" @default.
- W2224668502 hasLocation W22246685021 @default.
- W2224668502 hasOpenAccess W2224668502 @default.
- W2224668502 hasPrimaryLocation W22246685021 @default.
- W2224668502 hasRelatedWork W1693042156 @default.
- W2224668502 hasRelatedWork W2023369480 @default.
- W2224668502 hasRelatedWork W2067332738 @default.
- W2224668502 hasRelatedWork W2262924341 @default.
- W2224668502 hasRelatedWork W2336858858 @default.
- W2224668502 hasRelatedWork W2384560462 @default.
- W2224668502 hasRelatedWork W2416777901 @default.
- W2224668502 hasRelatedWork W2525509624 @default.
- W2224668502 hasRelatedWork W2603130073 @default.
- W2224668502 hasRelatedWork W2620976038 @default.
- W2224668502 hasRelatedWork W2724623883 @default.
- W2224668502 hasRelatedWork W2796801434 @default.
- W2224668502 hasRelatedWork W2799691978 @default.
- W2224668502 hasRelatedWork W2802058755 @default.
- W2224668502 hasRelatedWork W2901508016 @default.
- W2224668502 hasRelatedWork W2920672907 @default.
- W2224668502 hasRelatedWork W2974171924 @default.
- W2224668502 hasRelatedWork W2978673693 @default.
- W2224668502 hasRelatedWork W2993775113 @default.
- W2224668502 hasRelatedWork W3028973830 @default.
- W2224668502 hasVolume "16" @default.
- W2224668502 isParatext "false" @default.
- W2224668502 isRetracted "false" @default.
- W2224668502 magId "2224668502" @default.
- W2224668502 workType "article" @default.