FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224820439> ?p ?o ?g. }

• W2224820439 endingPage "e0146311" @default.
• W2224820439 startingPage "e0146311" @default.
• W2224820439 abstract "Background HER-targeted tyrosine kinase inhibitors (TKIs) have demonstrated pro-apoptotic and antiproliferative effects in vitro and in vivo. The exact pathways through which TKIs exert their antineoplastic effects are, however, still not completely understood. Methods Using Milliplex assays, we have investigated the effects of the three panHER-TKIs lapatinib, canertinib and afatinib on signal transduction cascade activation in SKBR3, T47D and Jurkat neoplastic cell lines. The growth-inhibitory effect of blockade of HER and of JNK and STAT5 signaling was measured by proliferation- and apoptosis-assays using formazan dye labeling of viable cells, Western blotting for cleaved PARP-1 and immunolabeling for active caspase 3, respectively. Results All three HER-TKIs clearly inhibited proliferation and increased apoptosis in HER2 overexpressing SKBR3 cells, while their effect was less pronounced on HER2 moderately expressing T47D cells where they exerted only a weak antiproliferative and essentially no pro-apoptotic effect. Remarkably, phosphorylation/activation of JNK and STAT5A/B were inhibited by HER-TKIs only in the sensitive, but not in the resistant cells. In contrast, phosphorylation/activation of ERK/MAPK, STAT3, CREB, p70 S6 kinase, IkBa, and p38 were equally affected by HER-TKIs in both cell lines. Moreover, we demonstrated that direct pharmacological blockade of JNK and STAT5 abrogates cell growth in both HER-TKI-sensitive as well as -resistant breast cancer cells, respectively. Conclusion We have shown that HER-TKIs exert a HER2 expression-dependent anti-cancer effect in breast cancer cell lines. This involves blockade of JNK and STAT5A/B signaling, which have been found to be required for in vitro growth of these cell lines." @default.
• W2224820439 created "2016-06-24" @default.
• W2224820439 creator A5015052494 @default.
• W2224820439 creator A5023306364 @default.
• W2224820439 creator A5025310604 @default.
• W2224820439 creator A5048876485 @default.
• W2224820439 creator A5066729241 @default.
• W2224820439 creator A5080636116 @default.
• W2224820439 date "2016-01-06" @default.
• W2224820439 modified "2023-10-14" @default.
• W2224820439 title "HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK" @default.
• W2224820439 cites W1590794385 @default.
• W2224820439 cites W1964321121 @default.
• W2224820439 cites W1974170604 @default.
• W2224820439 cites W1995242599 @default.
• W2224820439 cites W2005448278 @default.
• W2224820439 cites W2008021119 @default.
• W2224820439 cites W2023977554 @default.
• W2224820439 cites W2025357617 @default.
• W2224820439 cites W2050461681 @default.
• W2224820439 cites W2054541910 @default.
• W2224820439 cites W2054549250 @default.
• W2224820439 cites W2055854905 @default.
• W2224820439 cites W2057066413 @default.
• W2224820439 cites W2059817089 @default.
• W2224820439 cites W2073856071 @default.
• W2224820439 cites W2074730236 @default.
• W2224820439 cites W2087909560 @default.
• W2224820439 cites W2088145034 @default.
• W2224820439 cites W2088925787 @default.
• W2224820439 cites W2096959265 @default.
• W2224820439 cites W2103413641 @default.
• W2224820439 cites W2114095518 @default.
• W2224820439 cites W2114195503 @default.
• W2224820439 cites W2125947965 @default.
• W2224820439 cites W2126779285 @default.
• W2224820439 cites W2127154017 @default.
• W2224820439 cites W2131362842 @default.
• W2224820439 cites W2141425188 @default.
• W2224820439 cites W2145477245 @default.
• W2224820439 cites W2150059798 @default.
• W2224820439 cites W2152006092 @default.
• W2224820439 cites W2169816570 @default.
• W2224820439 cites W2171828245 @default.
• W2224820439 cites W2184278156 @default.
• W2224820439 cites W2405262285 @default.
• W2224820439 cites W2790805946 @default.
• W2224820439 doi "https://doi.org/10.1371/journal.pone.0146311" @default.
• W2224820439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4703392" @default.
• W2224820439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26735495" @default.
• W2224820439 hasPublicationYear "2016" @default.
• W2224820439 type Work @default.
• W2224820439 sameAs 2224820439 @default.
• W2224820439 citedByCount "18" @default.
• W2224820439 countsByYear W22248204392016 @default.
• W2224820439 countsByYear W22248204392017 @default.
• W2224820439 countsByYear W22248204392018 @default.
• W2224820439 countsByYear W22248204392019 @default.
• W2224820439 countsByYear W22248204392020 @default.
• W2224820439 countsByYear W22248204392021 @default.
• W2224820439 countsByYear W22248204392022 @default.
• W2224820439 crossrefType "journal-article" @default.
• W2224820439 hasAuthorship W2224820439A5015052494 @default.
• W2224820439 hasAuthorship W2224820439A5023306364 @default.
• W2224820439 hasAuthorship W2224820439A5025310604 @default.
• W2224820439 hasAuthorship W2224820439A5048876485 @default.
• W2224820439 hasAuthorship W2224820439A5066729241 @default.
• W2224820439 hasAuthorship W2224820439A5080636116 @default.
• W2224820439 hasBestOaLocation W22248204391 @default.
• W2224820439 hasConcept C121608353 @default.
• W2224820439 hasConcept C179464577 @default.
• W2224820439 hasConcept C184235292 @default.
• W2224820439 hasConcept C190283241 @default.
• W2224820439 hasConcept C191560914 @default.
• W2224820439 hasConcept C203014093 @default.
• W2224820439 hasConcept C2776090121 @default.
• W2224820439 hasConcept C2777329042 @default.
• W2224820439 hasConcept C2779786085 @default.
• W2224820439 hasConcept C2994423619 @default.
• W2224820439 hasConcept C502942594 @default.
• W2224820439 hasConcept C530470458 @default.
• W2224820439 hasConcept C54355233 @default.
• W2224820439 hasConcept C55493867 @default.
• W2224820439 hasConcept C57074206 @default.
• W2224820439 hasConcept C62112901 @default.
• W2224820439 hasConcept C62478195 @default.
• W2224820439 hasConcept C86803240 @default.
• W2224820439 hasConcept C8891405 @default.
• W2224820439 hasConcept C95444343 @default.
• W2224820439 hasConcept C96232424 @default.
• W2224820439 hasConceptScore W2224820439C121608353 @default.
• W2224820439 hasConceptScore W2224820439C179464577 @default.
• W2224820439 hasConceptScore W2224820439C184235292 @default.
• W2224820439 hasConceptScore W2224820439C190283241 @default.
• W2224820439 hasConceptScore W2224820439C191560914 @default.
• W2224820439 hasConceptScore W2224820439C203014093 @default.
• W2224820439 hasConceptScore W2224820439C2776090121 @default.
• W2224820439 hasConceptScore W2224820439C2777329042 @default.

• next