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- W2224830686 abstract "Radiation is an integral part of melanoma therapy, particularly for patients with symptomatic metastases. Efficient killing of tumor cells by radiation has been shown in immunocompromised mouse models to be enhanced greatly with transfer of a functioning immune system, particularly CD8+ T cells. In a subset of patients, addition of radiation to immunotherapy has also enhanced immune system-mediated tumor cell kill in non-irradiated areas, termed abscopal effect. This effect is thought to be a result of increased shedding of tumor antigens upon radiotherapy that primes the immune system to establish a more robust attack on melanoma cells throughout the body. Whether or not brain metastases in the blood brain barrier can be used to develop an abscopal effect is unknown. Pre-clinical reports support synergism between PD-1 inhibition and radiation in tumor killing and prolonged survival." @default.
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- W2224830686 date "2015-11-04" @default.
- W2224830686 modified "2023-09-28" @default.
- W2224830686 title "Harnessing the potential of radiation treatment of brain metastases to improve melanoma immunotherapy" @default.
- W2224830686 doi "https://doi.org/10.1186/2051-1426-3-s2-p367" @default.
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