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- W2224854747 abstract "We are all aware of the importance attached to tobacco smoke in the current debate on causes of respiratory disorders. Along with general atmospheric pollution, cigarette smoke is a major topic of discussion. It is not surprising, therefore, that much research has been devoted to histopathologic study of the respiratory tract after exposure to cigarette smoke, and to methods of registering physiologic changes in the respiratory mucosa. I do not propose to discuss histopathologic questions today. The physiologic functions which have attracted most attention are transportation of mucus and ciliary activity, and I shall now try to give a brief account of the observations hitherto published. I shall not attempt to describe the methods in detail, however, as these have already been discussed, and also because many of their authors are present here and are more competent than I to deal with such matters. Tobacco smoke is a composite of many substances. Research has sometimes been concentrated on the total smoke, and has sometimes been concerned with attempts to distinquish between the effects of a particulate phase and a gas phase, or to study the action of single, chemically well defined substances. Mendenhall and Shreeve described experiments with tobacco smoke as long ago as 1937 (1) and 1940 (2). They immersed calf tracheae in Tyrode's solution and observed the movement of carmine particles along the mucosa. The smoke was brought into contact with the trachea mainly by dissolving it in Tyrode's solution, which was then substituted for the original immersing fluid. Alternatively, the smoke was blown along the trachea, which was thereafter placed in Tyrode's solution. In all experiments the transit times were reduced by 17 to 40 per cent of the normal. A similar technique for observing the ciliastatic action of cigarette smoke was presented by Rakieten and his co-workers in 1952 (3)." @default.
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- W2224854747 date "1966-03-01" @default.
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- W2224854747 title "Effect of cigarette smoke on ciliary activity." @default.
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- W2224854747 doi "https://doi.org/10.1164/arrd.1966.93.3p2.108" @default.
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