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• W2224884516 abstract "HIV-infected individuals have a higher risk of being affected by serious illnesses , such as infections by respiratory viruses, including influenza virus . Immunosuppression of these individuals can affect their ability torespond to active immunization. Vaccination against influenza is still the main way to reduce the impact of this virus. Due to the movementin 2009 pandemic influenza A (H1N1)pdm09and seasonal influenza A (H3N2) and B viruses, the current vaccine composition include antigens of these three agents in their formulation. Thus, analysis of the impact of trivalent inactivated influenza vaccine (TIV) in HIV-infected individuals deserves further study. A cohort of 131 HIV-1 positive individuals with controlled viremia received two single doses of TIV 21 days apart. The titers of anti-hemagglutinant (HA) of their sera was assessedat different time points (zero, 21, 42 days and six months post-vaccination). With regard to immune to the virus A (H1N1)pdm09 response , it was noted that a year after having received the monovalent vaccine against this antigen , 62.6 % of subjects remained seroprotection , a decrease of 20 % compared to 6 monovalent months post-vaccination in 2010 . Moreover, after the first dose of TIV, seroprotective titers were found in allindividuals. The seroprotection baseline for H3N2 and influenza Bantigens was 67.9 % and 27.5 %, respectively. Regarding to seroconversion, we found that 19.8 % and 21 % of subjects had anti -hemagglutinin titles for the A (H1N1)pdm09, 21 and 42 days post-vaccination with TIV, respectively. Seroconversion for H3N2 antigen was 15.7% and 16 % at 21 and 42 days respectively. Regarding Influenza B, 35.7 % and 38.6 % of subjects seroconverted after 21 and 42 days after vaccination. At six months post-vaccination , the titers of anti -hemagglutinin sera fell below 15.7 % for antigen A (H1N1)pdm09, 14.4% to 29.1 % for H3N2 and influenza B antigens.We also observed that indviduos with higher CD4 cell counts resposram best vaccination against the influenza virus B. Together, our results indicate that HIV-1 positive individuals show better humoral responses to antigens A (H1N1) pdm09 compared with others two antigens present in the TIV." @default.
• W2224884516 created "2016-06-24" @default.
• W2224884516 creator A5081711640 @default.
• W2224884516 date "2014-01-01" @default.
• W2224884516 modified "2023-09-27" @default.
• W2224884516 title "Investigação da resposta imune humoral de indivíduos infectados pelo HIV-1 e vacinados contra as Influenza A(H1N1)pdm09, A/H3N2 e B" @default.
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