FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224886002> ?p ?o ?g. }

• W2224886002 endingPage "83" @default.
• W2224886002 startingPage "78" @default.
• W2224886002 abstract "A small-molecule inducer of apoptosis is able to kill senescent cells in the bone marrow of irradiated or aged mice, thereby improving hematopoietic stem cell function. Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)1,2,3,4,5,6. Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders7, suggesting that SCs play a causative role in certain age-related pathologies. Thus, a 'senolytic' pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span. To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type– and species-independent manner by inducing apoptosis. Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs). Notably, this depletion mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and MuSCs in normally aged mice. Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells. Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents." @default.
• W2224886002 created "2016-06-24" @default.
• W2224886002 creator A5001970748 @default.
• W2224886002 creator A5006035658 @default.
• W2224886002 creator A5007260460 @default.
• W2224886002 creator A5008419499 @default.
• W2224886002 creator A5014015669 @default.
• W2224886002 creator A5032539051 @default.
• W2224886002 creator A5034865670 @default.
• W2224886002 creator A5039030237 @default.
• W2224886002 creator A5039832836 @default.
• W2224886002 creator A5042249930 @default.
• W2224886002 creator A5054109175 @default.
• W2224886002 creator A5062293320 @default.
• W2224886002 creator A5063616750 @default.
• W2224886002 creator A5075158030 @default.
• W2224886002 creator A5079604421 @default.
• W2224886002 creator A5080240316 @default.
• W2224886002 creator A5089053875 @default.
• W2224886002 creator A5090720022 @default.
• W2224886002 date "2015-12-14" @default.
• W2224886002 modified "2023-10-18" @default.
• W2224886002 title "Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice" @default.
• W2224886002 cites W1489456875 @default.
• W2224886002 cites W1593388227 @default.
• W2224886002 cites W1977362098 @default.
• W2224886002 cites W1982481909 @default.
• W2224886002 cites W1985999015 @default.
• W2224886002 cites W1988233144 @default.
• W2224886002 cites W1991213319 @default.
• W2224886002 cites W1992336853 @default.
• W2224886002 cites W2004314923 @default.
• W2224886002 cites W2010345740 @default.
• W2224886002 cites W2013127588 @default.
• W2224886002 cites W2025666155 @default.
• W2224886002 cites W2026212073 @default.
• W2224886002 cites W2030509917 @default.
• W2224886002 cites W2044500107 @default.
• W2224886002 cites W2057485681 @default.
• W2224886002 cites W2068482381 @default.
• W2224886002 cites W2069519394 @default.
• W2224886002 cites W2084289371 @default.
• W2224886002 cites W2084619188 @default.
• W2224886002 cites W2087404852 @default.
• W2224886002 cites W2087877138 @default.
• W2224886002 cites W2088883749 @default.
• W2224886002 cites W2103911902 @default.
• W2224886002 cites W2108887402 @default.
• W2224886002 cites W2114514472 @default.
• W2224886002 cites W2115852450 @default.
• W2224886002 cites W2123468050 @default.
• W2224886002 cites W2126709547 @default.
• W2224886002 cites W2128807350 @default.
• W2224886002 cites W2130458932 @default.
• W2224886002 cites W2136700311 @default.
• W2224886002 cites W2138514622 @default.
• W2224886002 cites W2145578278 @default.
• W2224886002 cites W2156381379 @default.
• W2224886002 cites W2166822567 @default.
• W2224886002 cites W2168632005 @default.
• W2224886002 cites W2172242534 @default.
• W2224886002 cites W2230902569 @default.
• W2224886002 cites W2463972145 @default.
• W2224886002 cites W516190 @default.
• W2224886002 doi "https://doi.org/10.1038/nm.4010" @default.
• W2224886002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4762215" @default.
• W2224886002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26657143" @default.
• W2224886002 hasPublicationYear "2015" @default.
• W2224886002 type Work @default.
• W2224886002 sameAs 2224886002 @default.
• W2224886002 citedByCount "1171" @default.
• W2224886002 countsByYear W22248860022016 @default.
• W2224886002 countsByYear W22248860022017 @default.
• W2224886002 countsByYear W22248860022018 @default.
• W2224886002 countsByYear W22248860022019 @default.
• W2224886002 countsByYear W22248860022020 @default.
• W2224886002 countsByYear W22248860022021 @default.
• W2224886002 countsByYear W22248860022022 @default.
• W2224886002 countsByYear W22248860022023 @default.
• W2224886002 crossrefType "journal-article" @default.
• W2224886002 hasAuthorship W2224886002A5001970748 @default.
• W2224886002 hasAuthorship W2224886002A5006035658 @default.
• W2224886002 hasAuthorship W2224886002A5007260460 @default.
• W2224886002 hasAuthorship W2224886002A5008419499 @default.
• W2224886002 hasAuthorship W2224886002A5014015669 @default.
• W2224886002 hasAuthorship W2224886002A5032539051 @default.
• W2224886002 hasAuthorship W2224886002A5034865670 @default.
• W2224886002 hasAuthorship W2224886002A5039030237 @default.
• W2224886002 hasAuthorship W2224886002A5039832836 @default.
• W2224886002 hasAuthorship W2224886002A5042249930 @default.
• W2224886002 hasAuthorship W2224886002A5054109175 @default.
• W2224886002 hasAuthorship W2224886002A5062293320 @default.
• W2224886002 hasAuthorship W2224886002A5063616750 @default.
• W2224886002 hasAuthorship W2224886002A5075158030 @default.
• W2224886002 hasAuthorship W2224886002A5079604421 @default.
• W2224886002 hasAuthorship W2224886002A5080240316 @default.
• W2224886002 hasAuthorship W2224886002A5089053875 @default.
• W2224886002 hasAuthorship W2224886002A5090720022 @default.

• next