FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2224973710> ?p ?o ?g. }

• W2224973710 endingPage "608" @default.
• W2224973710 startingPage "597" @default.
• W2224973710 abstract "The administration in vivo of either adrenaline or glucagon alone resulted in increases of about 2-fold in the amounts of active, non-phosphorylated, pyruvate dehydrogenase in the livers of fed male or female rats, whereas when administered together increases of about 4-fold were obtained. Ca2+-dependent increases in the amount of active enzyme of up to about 5-fold could be achieved in isolated rat liver mitochondria by incubating them with increasing extramitochondrial [Ca2+]; from this, two conditions of Ca loading were chosen which caused increases in active enzyme similar to those with the hormone treatments given above. The increases in enzyme activity owing to these Ca loads persisted through the 're-isolation' of mitochondria and their incubation in Na+-free KCl-based media containing EGTA. Differences from values obtained with unloaded controls could be diminished by adding Na+ ions to cause the egress of Ca2+ from the mitochondria, or enough extramitochondrial Ca2+ to saturate the enzyme in its Ca2+-dependent activation; the effects of Na+ could be blocked by diltiazem, an inhibitor of mitochondrial Na+/Ca2+ exchange. The re-isolated, Ca-preloaded, mitochondria also exhibited enhanced activities of 2-oxoglutarate dehydrogenase when assayed at non-saturating [2-oxoglutarate] by two different methods; effects of Na+, Ca2+ or diltiazem on the persistent activations of this enzyme were similar to those for pyruvate dehydrogenase. Na+ caused a marked depletion, which could be blocked by diltiazem, of the 45Ca content of re-isolated mitochondria which had pre-loaded with Ca, containing 45Ca, to the same degrees as above. The activities of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase in incubated liver mitochondria prepared from rats subjected to the hormone treatments given above were found to behave in a very similar manner to those exhibited in the re-isolated, Ca-preloaded, mitochondria. It is concluded that these hormones each bring about the activations of these rat liver enzymes by causing increases in intramitochondrial [Ca2+], and that their effects, as such, are additive." @default.
• W2224973710 created "2016-06-24" @default.
• W2224973710 creator A5090970978 @default.
• W2224973710 date "1985-11-01" @default.
• W2224973710 modified "2023-10-15" @default.
• W2224973710 title "Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration" @default.
• W2224973710 cites W130184926 @default.
• W2224973710 cites W147821502 @default.
• W2224973710 cites W1495233477 @default.
• W2224973710 cites W1516678679 @default.
• W2224973710 cites W1517980505 @default.
• W2224973710 cites W1519784931 @default.
• W2224973710 cites W1531052981 @default.
• W2224973710 cites W1542197083 @default.
• W2224973710 cites W1545806139 @default.
• W2224973710 cites W1557027053 @default.
• W2224973710 cites W1562254619 @default.
• W2224973710 cites W1586112062 @default.
• W2224973710 cites W1598199924 @default.
• W2224973710 cites W1604711400 @default.
• W2224973710 cites W1633390167 @default.
• W2224973710 cites W1756031092 @default.
• W2224973710 cites W1861887801 @default.
• W2224973710 cites W193006127 @default.
• W2224973710 cites W1957691535 @default.
• W2224973710 cites W1959616763 @default.
• W2224973710 cites W1967707090 @default.
• W2224973710 cites W1974556814 @default.
• W2224973710 cites W1981296688 @default.
• W2224973710 cites W1983877797 @default.
• W2224973710 cites W1994924034 @default.
• W2224973710 cites W2002178679 @default.
• W2224973710 cites W2009827584 @default.
• W2224973710 cites W2028511251 @default.
• W2224973710 cites W2033776776 @default.
• W2224973710 cites W2033810389 @default.
• W2224973710 cites W2036145275 @default.
• W2224973710 cites W2036966244 @default.
• W2224973710 cites W2043992655 @default.
• W2224973710 cites W20444207 @default.
• W2224973710 cites W2045352028 @default.
• W2224973710 cites W2052159591 @default.
• W2224973710 cites W2052871573 @default.
• W2224973710 cites W2056285013 @default.
• W2224973710 cites W2062993845 @default.
• W2224973710 cites W2068877244 @default.
• W2224973710 cites W2078662366 @default.
• W2224973710 cites W2082288072 @default.
• W2224973710 cites W2085554856 @default.
• W2224973710 cites W2094789487 @default.
• W2224973710 cites W2094821743 @default.
• W2224973710 cites W2146927479 @default.
• W2224973710 cites W2160662624 @default.
• W2224973710 cites W2185116881 @default.
• W2224973710 cites W2203719020 @default.
• W2224973710 cites W2203986272 @default.
• W2224973710 cites W2207487345 @default.
• W2224973710 cites W2211155251 @default.
• W2224973710 cites W2225236708 @default.
• W2224973710 cites W2233127634 @default.
• W2224973710 cites W2233249081 @default.
• W2224973710 cites W2268076822 @default.
• W2224973710 cites W2287510495 @default.
• W2224973710 cites W2303673147 @default.
• W2224973710 cites W2336081906 @default.
• W2224973710 cites W2339058266 @default.
• W2224973710 cites W2340746202 @default.
• W2224973710 cites W2341014689 @default.
• W2224973710 cites W2344988655 @default.
• W2224973710 cites W2379698353 @default.
• W2224973710 cites W2397754537 @default.
• W2224973710 cites W2400196432 @default.
• W2224973710 cites W2400490263 @default.
• W2224973710 cites W2400779214 @default.
• W2224973710 cites W2400962914 @default.
• W2224973710 cites W2402037606 @default.
• W2224973710 cites W2411743811 @default.
• W2224973710 cites W2414160383 @default.
• W2224973710 cites W2437883705 @default.
• W2224973710 cites W263598675 @default.
• W2224973710 cites W278342722 @default.
• W2224973710 cites W45194730 @default.
• W2224973710 cites W59236889 @default.
• W2224973710 cites W86481594 @default.
• W2224973710 cites W87244597 @default.
• W2224973710 doi "https://doi.org/10.1042/bj2310597" @default.
• W2224973710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1152791" @default.
• W2224973710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3935105" @default.
• W2224973710 hasPublicationYear "1985" @default.
• W2224973710 type Work @default.
• W2224973710 sameAs 2224973710 @default.
• W2224973710 citedByCount "82" @default.
• W2224973710 countsByYear W22249737102016 @default.
• W2224973710 countsByYear W22249737102021 @default.
• W2224973710 crossrefType "journal-article" @default.
• W2224973710 hasAuthorship W2224973710A5090970978 @default.
• W2224973710 hasBestOaLocation W22249737102 @default.
• W2224973710 hasConcept C126093377 @default.

• next