Matches in SemOpenAlex for { <https://semopenalex.org/work/W2225079860> ?p ?o ?g. }
- W2225079860 endingPage "293" @default.
- W2225079860 startingPage "284" @default.
- W2225079860 abstract "Many patients with lung cancer, breast cancer, and melanoma develop brain metastases that are resistant to conventional therapy. The median survival for untreated patients is 1 to 2 months, which may be extended to 6 months with surgery, radiotherapy, and chemotherapy. The outcome of metastasis depends on multiple interactions of unique metastatic cells with host homeostatic mechanisms which the tumor cells exploit for their survival and proliferation. The blood-brain barrier is leaky in metastases that are larger than 0.5-mm diameter because of production of vascular endothelial growth factor by metastatic cells. Brain metastases are surrounded and infiltrated by microglia and activated astrocytes. The interaction with astrocytes leads to up-regulation of multiple genes in the metastatic cells, including several survival genes that are responsible for the increased resistance of tumor cells to cytotoxic drugs. These findings substantiate the importance of the seed and soil hypothesis and that successful treatment of brain metastases must include targeting of the organ microenvironment." @default.
- W2225079860 created "2016-06-24" @default.
- W2225079860 creator A5028562396 @default.
- W2225079860 date "2015-07-01" @default.
- W2225079860 modified "2023-10-18" @default.
- W2225079860 title "The Biology of Brain Metastasis" @default.
- W2225079860 cites W1258373536 @default.
- W2225079860 cites W1507790161 @default.
- W2225079860 cites W1520425169 @default.
- W2225079860 cites W1655177618 @default.
- W2225079860 cites W1679229092 @default.
- W2225079860 cites W182462426 @default.
- W2225079860 cites W1942671762 @default.
- W2225079860 cites W1964613075 @default.
- W2225079860 cites W1967251768 @default.
- W2225079860 cites W1968467234 @default.
- W2225079860 cites W1968519475 @default.
- W2225079860 cites W1971768361 @default.
- W2225079860 cites W1978328220 @default.
- W2225079860 cites W1978836458 @default.
- W2225079860 cites W1980664953 @default.
- W2225079860 cites W1986661911 @default.
- W2225079860 cites W1991805788 @default.
- W2225079860 cites W1992870310 @default.
- W2225079860 cites W1994099232 @default.
- W2225079860 cites W1995360312 @default.
- W2225079860 cites W1995954397 @default.
- W2225079860 cites W1997575011 @default.
- W2225079860 cites W1997702964 @default.
- W2225079860 cites W1998811052 @default.
- W2225079860 cites W2000837172 @default.
- W2225079860 cites W2001009147 @default.
- W2225079860 cites W2004220886 @default.
- W2225079860 cites W2004234324 @default.
- W2225079860 cites W2005342636 @default.
- W2225079860 cites W2011628003 @default.
- W2225079860 cites W2017691475 @default.
- W2225079860 cites W2019432079 @default.
- W2225079860 cites W2021250298 @default.
- W2225079860 cites W2022271244 @default.
- W2225079860 cites W2026584433 @default.
- W2225079860 cites W2039202448 @default.
- W2225079860 cites W2040425611 @default.
- W2225079860 cites W2042427065 @default.
- W2225079860 cites W2042935646 @default.
- W2225079860 cites W2049520769 @default.
- W2225079860 cites W2049640107 @default.
- W2225079860 cites W2050984501 @default.
- W2225079860 cites W2051467830 @default.
- W2225079860 cites W2060319077 @default.
- W2225079860 cites W2061593819 @default.
- W2225079860 cites W2062206584 @default.
- W2225079860 cites W2065843356 @default.
- W2225079860 cites W2066586472 @default.
- W2225079860 cites W2068776651 @default.
- W2225079860 cites W2081766968 @default.
- W2225079860 cites W2082679230 @default.
- W2225079860 cites W2086834847 @default.
- W2225079860 cites W2088730075 @default.
- W2225079860 cites W2088993386 @default.
- W2225079860 cites W2090625720 @default.
- W2225079860 cites W2094193890 @default.
- W2225079860 cites W2094660330 @default.
- W2225079860 cites W2095265260 @default.
- W2225079860 cites W2095931805 @default.
- W2225079860 cites W2096661713 @default.
- W2225079860 cites W2100820895 @default.
- W2225079860 cites W2101082342 @default.
- W2225079860 cites W2101506131 @default.
- W2225079860 cites W2103646648 @default.
- W2225079860 cites W2105536017 @default.
- W2225079860 cites W2108309130 @default.
- W2225079860 cites W2112880160 @default.
- W2225079860 cites W2116280632 @default.
- W2225079860 cites W2117691576 @default.
- W2225079860 cites W2119604317 @default.
- W2225079860 cites W2122828560 @default.
- W2225079860 cites W2123981075 @default.
- W2225079860 cites W2124085296 @default.
- W2225079860 cites W2128687105 @default.
- W2225079860 cites W2129008615 @default.
- W2225079860 cites W2132468732 @default.
- W2225079860 cites W2133857293 @default.
- W2225079860 cites W2134201651 @default.
- W2225079860 cites W2135212506 @default.
- W2225079860 cites W2135376726 @default.
- W2225079860 cites W2138302361 @default.
- W2225079860 cites W2143647842 @default.
- W2225079860 cites W2144171223 @default.
- W2225079860 cites W2144744111 @default.
- W2225079860 cites W2160935383 @default.
- W2225079860 cites W2163751922 @default.
- W2225079860 cites W2170343590 @default.
- W2225079860 cites W2314844425 @default.
- W2225079860 cites W2334321795 @default.
- W2225079860 cites W2341537876 @default.
- W2225079860 cites W2616418042 @default.
- W2225079860 cites W4244732711 @default.