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- W2225117589 abstract "The TRPV4 cation channel is expressed in a broad range of tissues where participates in the generation of a Ca2+ signal. TRPV4 participation in osmo- and mechanotransduction contributes to important functions such as cellular and systemic volume homeostasis, among others. TRPV4 also responds to temperature and 4α-phorbol 12,13-didecanoate (4αPDD) thus showing multiple modes of activation. Besides, dozens of TRPV4 mutations have been linked to osteoarticular and neuromuscular diseases. However, little is known about the domains relevant for TRPV4 activation by different stimuli. This Thesis research aims to elucidate the participation of the N-terminal cytosolic tail in the gating of TRPV4 by physiological stimuli and the channel implication in cell motility. I provide evidences that activation of TRPV4 by hypotonic shocks and temperature requires PIP2 binding within the sequence 121KRWRK125 of the N-terminus tail and rearrangement of the cytosolic tails. My results also point to the participation of TRPV4 in cell migration by modulating the dynamics of trailing adhesions, a function that may require the interplay of TRPV4 with other cation channels present at the focal adhesion sites.ResumenEl canal TRPV4 es un canal" @default.
- W2225117589 created "2016-06-24" @default.
- W2225117589 creator A5044225584 @default.
- W2225117589 date "2014-03-31" @default.
- W2225117589 modified "2023-09-24" @default.
- W2225117589 title "TRPV4 channel regulation and involvement in cell motility" @default.
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