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• W2225218643 abstract "s / Photodiagnosis and Photodynamic Therapy 12 (2015) 325–375 335 Modification of collagen fiber after PDT in porcine skin models by two photons microscopy analysis Priscila Fernanda Campos de Menezes1, Michelle Barreto Requena1, Ramon Gabriel Teixeira Rosa1, Sebastiao Pratavieira1, Alessandra Keiko Lima Fujita1, Cristina Kurachi1, Andre Escobar2, Rozana Wendler da Rocha2, Andrigo Barboza de Nardi2, Vanderlei S. Bagnato1 1 Sao Carlos Institute of Physics, University of Sao Paulo, Brazil 2 Department of Veterinary Clinic and Surgery, Faculty of Agriculture and Veterinary Sciences, Sao Paulo State University (UNESP), Jaboticabal, SP, Brazil Topical Photodynamic Therapy – PDTusingALA (aminolevulinic acid) ormethyl-ALA (MAL) asprecursor of protoporphyrin IX (PpIX) has been used in the skin cancer and rejuvenation treatment with successful. The PDT procedure stimulates high inflammatory process at skin that induces tissues necrosis followed by healing process. The healing process at skin occurred between 24h and 48h and after this. After PDT procedure the damage is established (necrosis process) and the modification in the type I collagen fiber occurs (collagen not functional). After this, the healing process elevates the amount of type I collagen fiber (functional). In this study, the modification of collagen fibers was evaluated after PDT procedure using ALA, and M-ALA cream and mixtures from both, in porcine skin models, by two photons microscopy analysis. The directions of collagenfiberweremeasured to all samples compared to the normal skin. The results obtained after 48h showed that only ALAcreamelevated thenumberof not functional collagenfiber. The mixturewith 50% fromboth showed elevated amount of functional collagen fiber. This results can be useful to PDT thinking in a therapy where is important to kill the tumor as well as to reconstruct the tissues. http://dx.doi.org/10.1016/j.pdpdt.2015.07.043 Photodynamic therapy combined to optical clearing agents for melanoma treatment Layla Pires1,2, Clovis Grecco1, Sebastiao Pratavieira1, Lilian Tan Moriyama1, Brian C. Wilson2, Cristina Kurachi1 1 Sao Carlos Institute of Physics, University of Sao Paulo, Brazil 2 Department of Medical Biophysics, University of Toronto, University Health Network, Toronto, Canada Melanoma is the most aggressive skin cancer type and its pigmentation has made it unsuitable for PDT. This study aims to evaluate the effect of optical clearing agents combinedwith PDT on melanoma treatment. Melanoma is the most aggressive skin cancer type and it is characterized by pigmented lesions with high tissue invasion and metastasis. The main therapeutic approach is lesion resection and, in some cases, lymph node dissection. Photodynamic therapy (PDT) is a technique already used for many cancers, mainly non-melanoma skin cancer. The high level of pigmentation in melanoma has made it unsuitable for PDT, since the light is very rapidly attenuated so that the full thickness cannot be reached. This study aims to evaluate the effect of optical clearing agents onmelanoma optical properties and then, on PDT response. Four optical clearing agents were evaluated in melanoma experimental model. The solutions were applied topically on the lesion and tissue optical properties evaluated by reflectance and OCT. Results showed changes in the total absorption coefficient up to 92% depending on the clearing agent used. After the clearing, the PDT was performed. Histology stained for H&E did not show residual lesion in the group treated with PDT combined to clearing agent. Immunohistochemistry assays still need to be performed. These initial results showed that optical clearing agents can change melanoma optical properties and may improve the PDT effect. http://dx.doi.org/10.1016/j.pdpdt.2015.07.044 5-ALA induced protoporphyrin IX fluorescence is a promising marker for identification of primary CNS lymphomas in stereotactic biopsies Mario Mischkulnig, Barbara Kiesel, Matthias Millesi, Stefan Wolfsberger, Engelbert Knosp, Georg Widhalm Department of Neurosurgery, Medical University, Vienna, Austria Background: The acquisition of non-diagnostic tissue samples during stereotactic biopsies of primary central nervous system lymphomas (PCNSL) is not uncommon. At present, no intraoperative marker for identification of PCNSL tissue is available. In the neurosurgical field, 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is used to visualize malignant gliomas during resection. The aim of this study was to analyze the value of PpIX fluorescence for visualization of tumor tissue during stereotactic biopsies of PCNSL. Methods: In 19 PCNSL patients, 5-ALA was administered prior to the diagnostic stereotactic biopsy. In each procedure, the tumor tissue derived from the biopsy target was investigated for the presence of visible PpIX fluorescence (strong, vague or none) with a modified neurosurgical microscope. Histopathological tumor diagnosis was established according to the World Health Organization (WHO) criteria in all cases. Results:StrongPpIXfluorescencewas found in18patients (95%) during stereotactic biopsy, whereas no fluorescence was detected in the remaining case (5%). In all patients with visible PpIX fluorescence diagnostic PCNSL tissue was found. Conclusion: 5-ALA induced PpIX fluorescence is a promising marker for identification of PCNSL during stereotactic biopsies and may therefore minimize the risk of acquisition of non-diagnostic tissue samples. http://dx.doi.org/10.1016/j.pdpdt.2015.07.045 Evaluation of 5-ALA induced protoporphyrin IX fluorescence in intracranial meningiomas Georg Widhalm, Matthias Millesi, Barbara Kiesel, Mario Mischkulnig, Stefan Wolfsberger, Engelbert Knosp Department of Neurosurgery, Medical University" @default.
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• W2225218643 date "2015-09-01" @default.
• W2225218643 modified "2023-10-04" @default.
• W2225218643 title "Modification of collagen fiber after PDT in porcine skin models by two photons microscopy analysis" @default.
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