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- W2225235148 abstract "303 Mutations in the Toll-like receptor/ MYD88 pathway in young (£50 years) CLL patients Alejandra Martinez-Trillos, Magda Pinyol, Alba Navarro, Marta Aymerich, Pedro Jares, Manel Juan, Maria Rozman, Dolors Colomer, Julio Delgado, Eva Gine, Marcos Gonzalez-Diaz, Jesus M. Hernandez-Rivas, Enrique Colado, Consolacion Rayon, Angel R. Payer, Maria Jose Terol, Blanca Navarro, Victor Quesada, Xose S. Puente, Ciril Rozman, Carlos Lopez-Otin, Elias Campo, Armando Lopez-Guillermo, PhD MD, Neus Villamor Unitat d’Hematopatologia, Servei d’Anatomia Patologica, Hospital Clinic de Barcelona; IDIBAPS, Unitat de Genomica; Servei d’Inmunologia, Hospital Clinic de Barcelona; Unitat d’Hematopatologia, Servei d’Anatomia Patologica, Hospital Clinic de Barcelona; Unitat de Genomica, Unitat de Genomica, IDIBAPS; Servicio de Hematologia, Hospital Clinico Universitario, IBMCC, IBSAL, Centro de Investigacion del Cancer (USAL-CSIC), Universidad de Salamanca; Servicio de Hematologia, Hospital Universitario Central de Asturias; Servicio de Hematologia, Hospital Clinico de Valencia; Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo; Josep Carreras Leukemia Research Institute, Barcelona; Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo Table Main clinical and biological characteristics of 146 CLL patie Parameter Category Unmuta (n[12 Gender Male (%) 85 (6 Age (years), median (range) 44 (2 0 44/126 (3 Rai stage I-II 77/126 (6 III-IV 5/126 (4 Monoclonal component 7/127(6 b2microglobulin UNV 40/103 (3 IGHV Mutated 43/99 (4 CD38 <30% 64/106 (6 ZAP-70 <20% 53/100 (5 Del(13q)(q14.3) 34/84 (4 Trisomy 12 11/85 (1 Genetics Del(11q)(q22.3) 12/83 (1 Del(17p)(p13.1) 3/83 (4 NOTCH1 Mutated 9/112 (8 SF3B1 Mutated 10/86 (1 TP53 Mutated 2/73 (3 10-year TTT (95% CI) AB p1⁄40.02) at 10 years, and was not different from that of normal population. This study identifies TLR/MYD88 mutations as the most frequent in young CLL patients, it is associated with a favorable outcome and it may be relevant for the clinical management of these patients. nts £50 years of age according to TLR/MYD88 mutations ted 7) Mutated (n[19) p 7%) 13 (68%) ns 4-50) 43(32-49) ns 5%) 3/19 (16%) 1%) 13/19 (68%) 0.045 %) 3/19 (16%) %) 4/19 (21%) 0.038 9%) 1/15 (7%) 0.013 4%) 15/17 (88%) <0.001 0%) 17/18 (94%) 0.006 3%) 18/18 (100%) <0.001 0%) 8/14 (57%) ns 3%) 1/14 (7%) ns 4%) 1/14 (7%) ns %) 0/14 (0%) ns %) 0/18 (0%) ns 2%) 1/14 (7%) ns %) 0/13 (0%) ns 5-83) 37% (11-64) 0.07 5-75) 100% 0.02 Clinical Lymphoma, Myeloma & Leukemia June 2015 S203" @default.
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- W2225235148 date "2015-06-01" @default.
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- W2225235148 title "Mutations in the Toll-like receptor/MYD88 pathway in young (≤50 years) CLL patients" @default.
- W2225235148 doi "https://doi.org/10.1016/j.clml.2015.04.063" @default.
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