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- W2225264612 abstract "Background: To evaluate the effect of autologous hematopoietic CD34+ cell transplantation (HCT) on diabetic neuropathy in patients with type 2 diabetes mellitus. Materials and Methods: We recruited ambulatory patients with type 2 diabetes and diabetic neuropathy as defined by the consensus of San Antonio without other active comorbidities. After s.c. filgrastim administration for 4 days, patients were randomized to a treatment group (intervened with autologous intramuscular HCT on the gastrocnemius region) or to a placebo group (intervened with autologous intramuscular plasma on the same region). Patients were evaluated by blinded personnel at the beginning and 3 months later by nerve conduction velocities (NCV) of lower extremities. Successful outcomes were defined as an improvement in NCV. Results: Twenty patients were included, 15 in the treatment group and 5 in the placebo group. Both groups had successful outcomes in the left peroneal NCV, independent of the number of CD34+ cells transplanted. The differences between groups were not statistically significant. Conclusions: Although we found improvement in NCV with autologous HCT, we propose further studies to determine the effect of transplantation on diabetic neuropathy." @default.
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- W2225264612 date "2010-01-01" @default.
- W2225264612 modified "2023-10-17" @default.
- W2225264612 title "Efecto del trasplante autólogo de células madre hematopoyéticas en la velocidad de conducción nerviosa en pacientes con diabetes mellitus tipo 2" @default.
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