FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2225508441> ?p ?o ?g. }

• W2225508441 endingPage "133" @default.
• W2225508441 startingPage "127" @default.
• W2225508441 abstract "The serotonin system plays an important role in the pathogenesis of major depressive disorder (MDD) and genetic variations in serotonin-related genes affect the efficacy of antidepressants. The aim of this study was to investigate the relationship between genotypic variation in six candidate serotonergic genes (ADCY9, HTR1B, GNB3, HTR2A, TPH2, SLC6A4) and depressive and anxiety symptom severity trajectories as well as remission following escitalopram treatment. A total of 166 Chinese patients with MDD were treated with escitalopram (open-label) for 8 weeks. TPH2 rs4570625 GG carriers were more likely to achieve depressive and anxiety symptom remission compared with T-allele carriers. At the trend level (Pcorrected=0.05), depressive symptom severity trajectories were moderated by TPH2 rs4570625. Patients with the GT or the GG genotype showed more favorable depressive symptom severity trajectories compared with TT genotype carriers. Polymorphisms in ADCY9, HTR1B, and HTR2A were nominally associated with symptom remission, but did not withstand correction for multiple comparisons. The HTTLPR polymorphism was not included in our final analysis because of a high percentage of missing data. These results suggested that genotypic variation in TPH2 may moderate the therapeutic response to esciatlopram among Chinese patients with MDD." @default.
• W2225508441 created "2016-06-24" @default.
• W2225508441 creator A5033351939 @default.
• W2225508441 creator A5041623562 @default.
• W2225508441 creator A5050383026 @default.
• W2225508441 creator A5051610618 @default.
• W2225508441 creator A5052436599 @default.
• W2225508441 creator A5057262700 @default.
• W2225508441 creator A5059151889 @default.
• W2225508441 creator A5088135944 @default.
• W2225508441 date "2016-05-01" @default.
• W2225508441 modified "2023-10-17" @default.
• W2225508441 title "Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment" @default.
• W2225508441 cites W105908140 @default.
• W2225508441 cites W1834926699 @default.
• W2225508441 cites W1966937313 @default.
• W2225508441 cites W1970498796 @default.
• W2225508441 cites W1970506215 @default.
• W2225508441 cites W1977874045 @default.
• W2225508441 cites W1978608546 @default.
• W2225508441 cites W1978742008 @default.
• W2225508441 cites W1989537794 @default.
• W2225508441 cites W1992204010 @default.
• W2225508441 cites W1993159686 @default.
• W2225508441 cites W1994516975 @default.
• W2225508441 cites W1999913805 @default.
• W2225508441 cites W2008582715 @default.
• W2225508441 cites W2021449356 @default.
• W2225508441 cites W2022951276 @default.
• W2225508441 cites W2053701135 @default.
• W2225508441 cites W2058702631 @default.
• W2225508441 cites W2059815221 @default.
• W2225508441 cites W2074404972 @default.
• W2225508441 cites W2082842896 @default.
• W2225508441 cites W2083020792 @default.
• W2225508441 cites W2087484885 @default.
• W2225508441 cites W2087488436 @default.
• W2225508441 cites W2099120666 @default.
• W2225508441 cites W2103748523 @default.
• W2225508441 cites W2126068921 @default.
• W2225508441 cites W2131678896 @default.
• W2225508441 cites W2143110843 @default.
• W2225508441 cites W2161011520 @default.
• W2225508441 cites W2161633633 @default.
• W2225508441 cites W2162176738 @default.
• W2225508441 cites W3131813341 @default.
• W2225508441 cites W4244552886 @default.
• W2225508441 cites W2044128658 @default.
• W2225508441 doi "https://doi.org/10.1097/yic.0000000000000115" @default.
• W2225508441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26745768" @default.
• W2225508441 hasPublicationYear "2016" @default.
• W2225508441 type Work @default.
• W2225508441 sameAs 2225508441 @default.
• W2225508441 citedByCount "10" @default.
• W2225508441 countsByYear W22255084412017 @default.
• W2225508441 countsByYear W22255084412018 @default.
• W2225508441 countsByYear W22255084412020 @default.
• W2225508441 countsByYear W22255084412021 @default.
• W2225508441 countsByYear W22255084412022 @default.
• W2225508441 countsByYear W22255084412023 @default.
• W2225508441 crossrefType "journal-article" @default.
• W2225508441 hasAuthorship W2225508441A5033351939 @default.
• W2225508441 hasAuthorship W2225508441A5041623562 @default.
• W2225508441 hasAuthorship W2225508441A5050383026 @default.
• W2225508441 hasAuthorship W2225508441A5051610618 @default.
• W2225508441 hasAuthorship W2225508441A5052436599 @default.
• W2225508441 hasAuthorship W2225508441A5057262700 @default.
• W2225508441 hasAuthorship W2225508441A5059151889 @default.
• W2225508441 hasAuthorship W2225508441A5088135944 @default.
• W2225508441 hasConcept C104317684 @default.
• W2225508441 hasConcept C118552586 @default.
• W2225508441 hasConcept C126322002 @default.
• W2225508441 hasConcept C135763542 @default.
• W2225508441 hasConcept C143998085 @default.
• W2225508441 hasConcept C149737253 @default.
• W2225508441 hasConcept C15744967 @default.
• W2225508441 hasConcept C170493617 @default.
• W2225508441 hasConcept C180754005 @default.
• W2225508441 hasConcept C2775864247 @default.
• W2225508441 hasConcept C2779177272 @default.
• W2225508441 hasConcept C2779583969 @default.
• W2225508441 hasConcept C2779999352 @default.
• W2225508441 hasConcept C2780051608 @default.
• W2225508441 hasConcept C2780733359 @default.
• W2225508441 hasConcept C37000724 @default.
• W2225508441 hasConcept C54355233 @default.
• W2225508441 hasConcept C558461103 @default.
• W2225508441 hasConcept C70410870 @default.
• W2225508441 hasConcept C71924100 @default.
• W2225508441 hasConcept C86803240 @default.
• W2225508441 hasConceptScore W2225508441C104317684 @default.
• W2225508441 hasConceptScore W2225508441C118552586 @default.
• W2225508441 hasConceptScore W2225508441C126322002 @default.
• W2225508441 hasConceptScore W2225508441C135763542 @default.
• W2225508441 hasConceptScore W2225508441C143998085 @default.
• W2225508441 hasConceptScore W2225508441C149737253 @default.
• W2225508441 hasConceptScore W2225508441C15744967 @default.
• W2225508441 hasConceptScore W2225508441C170493617 @default.

• next