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- W2225520394 abstract "CD138 (also termed SDC1) has been the gold-standard surface marker to detect multiple myeloma (MM) cells for decades; however, drug-resistant residual and circulating MM cells were shown to have lower expression of this marker. In this study, we have shown that residual MM cells following bortezomib treatment are hypoxic. This combination of drug exposure and hypoxia down-regulates their CD138 expression, thereby making this marker unsuitable for detecting residual or other hypoxic MM cells, such as circulating tumour cells, in MM. Hence, we developed an alternative biomarker set which detects myeloma cells independent of their hypoxic and CD138 expression status in vitro, in vivo and in primary MM patients. The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients. Further investigation to characterize the role of this population as a prognostic marker in MM is warranted." @default.
- W2225520394 created "2016-06-24" @default.
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- W2225520394 date "2016-01-05" @default.
- W2225520394 modified "2023-10-18" @default.
- W2225520394 title "A CD138-independent strategy to detect minimal residual disease and circulating tumour cells in multiple myeloma" @default.
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- W2225520394 doi "https://doi.org/10.1111/bjh.13927" @default.
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