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• W2225570835 abstract "There has been a growing interest in the role of the endogenous cannabinoid system in the regulation of emotional states. The behavioral interaction between stress and cannabinoids seems to have different patterns depending on the stress carried out, i.e.: acute, repeated or variable stress. In this study, we evaluated and compared the alterations induced by two types of stress, the neonatal isolation and restraint stress. The neonatal isolation procedure was performed for 7 days – post-natal day 2 to 9 - when each pup was placed in an individual round plastic container, with no bedding, remaining for 1 h at 30°C. On the other hand, in the restraint stress procedure, 80 days old rats were immobilized in a wire chamber for 2 h. The administration of the CB 1 receptor agonist WIN 55,212-2 (0.25; 0.75 and 1.25 mg/kg i.p.) was used to evaluate the effects of these two stress-procedures over cannabinoid responses of adult rats tested in the elevated plus-maze. The main finding was that only in restraint stressed animals the administration of the CB 1 receptor agonist – WIN 55,212-2 - was able to interact with stress to alter the behavior of adult rats. Hence, this effect indicates that stress differentially modulates behavioral responses to this cannabinoid agonist in the elevated plus maze. The present study suggests that future research evaluating the potential use of cannabis derivates in anti-anxiety therapies should consider the distinct interaction between different types of stress and the effects of cannabinoids." @default.
• W2225570835 created "2016-06-24" @default.
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• W2225570835 date "2014-08-12" @default.
• W2225570835 modified "2023-09-27" @default.
• W2225570835 title "Stress differentially modulates behavioral responses to the cannabinoid agonist, WIN 55,212-2, in adult rats" @default.
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