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- W2225687364 abstract "ConclusionBoth acute and chronic hypoxia alter resting [Ca2+]i value and Ca2+ transients in PASMCs. These alterations are related to hypoxia-mediated effects on various pathways implicated in PASMC Ca2+ homeostasis: voltage-dependent and-independent Ca2+ influx, IP3R5Ca2+ re-uptake, etc. These alterations also play a role in both structural and reactivity changes of the pulmonary circulation in the course of the development of PAHT, as well as in its potential reversal upon normal air breathing. Further studies are therefore required to provide a comprehensive description of the variety of hypoxia-induced effects on calcium signaling in PASMCs, and to identify the common mechanism(s) leading to these various effects in order to define new molecular therapeutic targets." @default.
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- W2225687364 date "2006-02-22" @default.
- W2225687364 modified "2023-09-23" @default.
- W2225687364 title "Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells" @default.
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