Matches in SemOpenAlex for { <https://semopenalex.org/work/W2225696827> ?p ?o ?g. }
- W2225696827 endingPage "155" @default.
- W2225696827 startingPage "144" @default.
- W2225696827 abstract "Whereas protease inhibitors have been developed successfully against hypertension and viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling we now better understand that the tumor “degradome” (i.e. the repertoire of proteases and their natural inhibitors and interaction partners) forms a complex network in which specific nodes determine the global outcome of manipulation of the protease web. However, knowing which proteases are active in the tumor micro-environment, we may tackle cancers with the use of Protease-Activated Prodrugs (PAPs). Here we exemplify this concept for metallo-, cysteine and serine proteases. PAPs not only exist as small molecular adducts, containing a cleavable substrate sequence and a latent prodrug, they are presently also manufactured as various types of nanoparticles. Although the emphasis of this review is on PAPs for treatment, it is clear that protease activatable probes and nanoparticles are also powerful tools for imaging purposes, including tumor diagnosis and staging, as well as visualization of tumor imaging during microsurgical resections." @default.
- W2225696827 created "2016-06-24" @default.
- W2225696827 creator A5025019174 @default.
- W2225696827 creator A5048493199 @default.
- W2225696827 creator A5049802073 @default.
- W2225696827 creator A5060562558 @default.
- W2225696827 date "2016-02-01" @default.
- W2225696827 modified "2023-09-30" @default.
- W2225696827 title "Proteases in cancer drug delivery" @default.
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