FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2225942893> ?p ?o ?g. }

• W2225942893 abstract "Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that functions as a microtubule stabiliser. Depletion of NuSAP leads to severe mitotic defects, however the mechanism by which NuSAP regulates mitosis remains elusive. In this study, we identify the microtubule depolymeriser, mitotic centromere-associated kinesin (MCAK), as a novel binding partner of NuSAP. We show that NuSAP regulates the dynamics and depolymerisation activity of MCAK. Phosphorylation of MCAK by Aurora B kinase, a component of the chromosomal passenger complex, significantly enhances the interaction of NuSAP with MCAK and modulates the effects of NuSAP on the depolymerisation activity of MCAK. Our results reveal an underlying mechanism by which NuSAP controls kinetochore microtubule dynamics spatially and temporally by modulating the depolymerisation function of MCAK in an Aurora B kinase-dependent manner. Hence, this study provides new insights into the function of NuSAP in spindle formation during mitosis." @default.
• W2225942893 created "2016-06-24" @default.
• W2225942893 creator A5022640003 @default.
• W2225942893 creator A5038787586 @default.
• W2225942893 creator A5039933841 @default.
• W2225942893 creator A5054715840 @default.
• W2225942893 creator A5072699872 @default.
• W2225942893 creator A5077821208 @default.
• W2225942893 creator A5086294527 @default.
• W2225942893 date "2016-01-06" @default.
• W2225942893 modified "2023-10-17" @default.
• W2225942893 title "NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity" @default.
• W2225942893 cites W1965330808 @default.
• W2225942893 cites W1965404941 @default.
• W2225942893 cites W1966306002 @default.
• W2225942893 cites W1966665398 @default.
• W2225942893 cites W1973082742 @default.
• W2225942893 cites W1977913984 @default.
• W2225942893 cites W1981838143 @default.
• W2225942893 cites W1983012321 @default.
• W2225942893 cites W1983875760 @default.
• W2225942893 cites W1986092065 @default.
• W2225942893 cites W1987280449 @default.
• W2225942893 cites W1995050894 @default.
• W2225942893 cites W2003725510 @default.
• W2225942893 cites W2006811655 @default.
• W2225942893 cites W2009824440 @default.
• W2225942893 cites W2016462887 @default.
• W2225942893 cites W2023469279 @default.
• W2225942893 cites W2024091015 @default.
• W2225942893 cites W2029041966 @default.
• W2225942893 cites W2032733101 @default.
• W2225942893 cites W2039146647 @default.
• W2225942893 cites W2039549200 @default.
• W2225942893 cites W2041020776 @default.
• W2225942893 cites W2046089519 @default.
• W2225942893 cites W2050953095 @default.
• W2225942893 cites W2064298185 @default.
• W2225942893 cites W2068843702 @default.
• W2225942893 cites W2069283145 @default.
• W2225942893 cites W2070996651 @default.
• W2225942893 cites W2072443704 @default.
• W2225942893 cites W2073846917 @default.
• W2225942893 cites W2077278490 @default.
• W2225942893 cites W2079900102 @default.
• W2225942893 cites W2083003255 @default.
• W2225942893 cites W2083098825 @default.
• W2225942893 cites W2092401565 @default.
• W2225942893 cites W2096509200 @default.
• W2225942893 cites W2107059185 @default.
• W2225942893 cites W2107913178 @default.
• W2225942893 cites W2108192944 @default.
• W2225942893 cites W2110944043 @default.
• W2225942893 cites W2111645250 @default.
• W2225942893 cites W2117121945 @default.
• W2225942893 cites W2130364109 @default.
• W2225942893 cites W2132005771 @default.
• W2225942893 cites W2132472784 @default.
• W2225942893 cites W2136961873 @default.
• W2225942893 cites W2137262057 @default.
• W2225942893 cites W2138429565 @default.
• W2225942893 cites W2138958608 @default.
• W2225942893 cites W2142128650 @default.
• W2225942893 cites W2143174721 @default.
• W2225942893 cites W2148418137 @default.
• W2225942893 cites W2150287123 @default.
• W2225942893 cites W2152166381 @default.
• W2225942893 cites W2161101708 @default.
• W2225942893 cites W2165775966 @default.
• W2225942893 cites W2166102124 @default.
• W2225942893 cites W2167835288 @default.
• W2225942893 cites W2168881161 @default.
• W2225942893 cites W2172153870 @default.
• W2225942893 cites W2439107306 @default.
• W2225942893 doi "https://doi.org/10.1038/srep18773" @default.
• W2225942893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4702128" @default.
• W2225942893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26733216" @default.
• W2225942893 hasPublicationYear "2016" @default.
• W2225942893 type Work @default.
• W2225942893 sameAs 2225942893 @default.
• W2225942893 citedByCount "29" @default.
• W2225942893 countsByYear W22259428932016 @default.
• W2225942893 countsByYear W22259428932017 @default.
• W2225942893 countsByYear W22259428932018 @default.
• W2225942893 countsByYear W22259428932019 @default.
• W2225942893 countsByYear W22259428932020 @default.
• W2225942893 countsByYear W22259428932021 @default.
• W2225942893 countsByYear W22259428932022 @default.
• W2225942893 countsByYear W22259428932023 @default.
• W2225942893 crossrefType "journal-article" @default.
• W2225942893 hasAuthorship W2225942893A5022640003 @default.
• W2225942893 hasAuthorship W2225942893A5038787586 @default.
• W2225942893 hasAuthorship W2225942893A5039933841 @default.
• W2225942893 hasAuthorship W2225942893A5054715840 @default.
• W2225942893 hasAuthorship W2225942893A5072699872 @default.
• W2225942893 hasAuthorship W2225942893A5077821208 @default.
• W2225942893 hasAuthorship W2225942893A5086294527 @default.
• W2225942893 hasBestOaLocation W22259428931 @default.
• W2225942893 hasConcept C104317684 @default.
• W2225942893 hasConcept C121332964 @default.

• next