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• W2225970644 abstract "HE LUNGS FREQUENTLY experience toxicity related to antineoplastic chemotherapy. Ten to twenty percent of patients treated with chemotherapy develop pulmonary complications. 1,2 Although some toxicities can be prevented and/or effectively treated, other presentations can be severe and rapidly fatal. The clinical presentation and radiographic appearance of these complications are most often nonspecific, and may, in particular, be difficult to distinguish from infectious complications to which this population is prone because of immunosuppression. The picture may be confounded further by the presence of lung metastases from the underlying cancer. There are no available universal criteria for the diagnosis of drug-induced pulmonary toxicity, therefore the diagnosis generally depends on an appropriate history of drug exposure, histologic evidence of lung injury, and, most importantly, the exclusion of other causes of the lung injury. Chemotherapy-induced lung disease was recognized first in the early 1960s in association with busulfan. 3 Antineoplastic agents known specifically to cause pulmonary injury include bleomycin and methotrexate. 4 Currently, pulmonary toxicity due to chemotherapy commonly is encountered, due to patients being exposed to a variety of standard antineoplastic agents, as well as a host of newer agents (Table 1). There is a paucity of literature (especially recent) discussing the perioperative management of patients treated with chemotherapy agents having potential lung toxicity. This manuscript summarizes available data on pulmonary toxicity of chemotherapy and potential implications for the anesthesiologist." @default.
• W2225970644 created "2016-06-24" @default.
• W2225970644 creator A5024334808 @default.
• W2225970644 date "2017-12-01" @default.
• W2225970644 modified "2023-09-25" @default.
• W2225970644 title "Chemotherapy Agents With Known Pulmonary Side Effects and Their Anesthetic and Critical Care Implications" @default.
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• W2225970644 doi "https://doi.org/10.1053/j.jvca.2015.06.019" @default.
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