Matches in SemOpenAlex for { <https://semopenalex.org/work/W222642912> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W222642912 endingPage "81" @default.
- W222642912 startingPage "1075" @default.
- W222642912 abstract "It has been shown that genetic factors within the HLA region are involved in the etiology of several diseases. For some of these, the existence of another genetic factor has been suggested, although not proven. A possible way to give evidence for another locus (G) is to show that the disease and an unlinked HLA-marker locus (M) do not segregate independently. The usual lod-score method, which assumes monogenic inheritance, is inappropriate for this test. We propose a correction of this method for performing a linkage analysis between the G and M loci, taking into account the role of HLA. A very simple way of using the HLA information is by modifying, for each individual of a pedigree, the penetrance values at the G locus according to the number of HLA haplotypes shared with the index case. These penetrance values are inferred from the observed IBD (identity-by-descent) distribution of HLA haplotypes in a sample of affected sib-pairs. The advantage of using this empirical distribution is that it is not based on any assumptions concerning the mode of inheritance at the HLA-linked locus. This correction method was established using a two-locus model with restrictive assumptions. Its value is discussed for various sets of parameters in more general and realistic two-locus models using simulations." @default.
- W222642912 created "2016-06-24" @default.
- W222642912 creator A5059520525 @default.
- W222642912 creator A5068798678 @default.
- W222642912 creator A5081264276 @default.
- W222642912 date "1984-09-01" @default.
- W222642912 modified "2023-09-23" @default.
- W222642912 title "HLA-associated diseases: a new method for performing linkage analysis with other markers than HLA." @default.
- W222642912 cites W1505797643 @default.
- W222642912 cites W1643869946 @default.
- W222642912 cites W1999758760 @default.
- W222642912 cites W2009919323 @default.
- W222642912 cites W2066367109 @default.
- W222642912 cites W2092623157 @default.
- W222642912 cites W2093943045 @default.
- W222642912 cites W2130531793 @default.
- W222642912 cites W339724285 @default.
- W222642912 cites W62431344 @default.
- W222642912 cites W96717503 @default.
- W222642912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1684504" @default.
- W222642912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6594041" @default.
- W222642912 hasPublicationYear "1984" @default.
- W222642912 type Work @default.
- W222642912 sameAs 222642912 @default.
- W222642912 citedByCount "0" @default.
- W222642912 crossrefType "journal-article" @default.
- W222642912 hasAuthorship W222642912A5059520525 @default.
- W222642912 hasAuthorship W222642912A5068798678 @default.
- W222642912 hasAuthorship W222642912A5081264276 @default.
- W222642912 hasConcept C104317684 @default.
- W222642912 hasConcept C127716648 @default.
- W222642912 hasConcept C142870003 @default.
- W222642912 hasConcept C147483822 @default.
- W222642912 hasConcept C178221405 @default.
- W222642912 hasConcept C180754005 @default.
- W222642912 hasConcept C188280979 @default.
- W222642912 hasConcept C197754878 @default.
- W222642912 hasConcept C200544954 @default.
- W222642912 hasConcept C2775866039 @default.
- W222642912 hasConcept C54355233 @default.
- W222642912 hasConcept C84597430 @default.
- W222642912 hasConcept C86803240 @default.
- W222642912 hasConceptScore W222642912C104317684 @default.
- W222642912 hasConceptScore W222642912C127716648 @default.
- W222642912 hasConceptScore W222642912C142870003 @default.
- W222642912 hasConceptScore W222642912C147483822 @default.
- W222642912 hasConceptScore W222642912C178221405 @default.
- W222642912 hasConceptScore W222642912C180754005 @default.
- W222642912 hasConceptScore W222642912C188280979 @default.
- W222642912 hasConceptScore W222642912C197754878 @default.
- W222642912 hasConceptScore W222642912C200544954 @default.
- W222642912 hasConceptScore W222642912C2775866039 @default.
- W222642912 hasConceptScore W222642912C54355233 @default.
- W222642912 hasConceptScore W222642912C84597430 @default.
- W222642912 hasConceptScore W222642912C86803240 @default.
- W222642912 hasIssue "5" @default.
- W222642912 hasLocation W2226429121 @default.
- W222642912 hasOpenAccess W222642912 @default.
- W222642912 hasPrimaryLocation W2226429121 @default.
- W222642912 hasRelatedWork W1518689009 @default.
- W222642912 hasRelatedWork W1525365989 @default.
- W222642912 hasRelatedWork W1969139433 @default.
- W222642912 hasRelatedWork W1993759323 @default.
- W222642912 hasRelatedWork W2004129265 @default.
- W222642912 hasRelatedWork W2049234958 @default.
- W222642912 hasRelatedWork W2115312134 @default.
- W222642912 hasRelatedWork W222642912 @default.
- W222642912 hasRelatedWork W2993685795 @default.
- W222642912 hasRelatedWork W3115610476 @default.
- W222642912 hasVolume "36" @default.
- W222642912 isParatext "false" @default.
- W222642912 isRetracted "false" @default.
- W222642912 magId "222642912" @default.
- W222642912 workType "article" @default.