FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2226452986> ?p ?o ?g. }

• W2226452986 endingPage "901" @default.
• W2226452986 startingPage "892" @default.
• W2226452986 abstract "Dried blood spots (DBS) are a versatile and stable tool for direct clinical blood analysis. Ambient high-resolution mass spectrometry is emerging as a method of choice for their quantitative analysis, for instance in therapeutic drug monitoring. Here, we coupled liquid microjunction surface sampling technology, a so-called Flowprobe, with an Orbitrap mass spectrometer and demonstrated the utility of this set-up for direct quantification of multiple drugs in DBS on filter paper. A three-layer set-up that we had introduced earlier enabled introduction of internal standards into DBS. We furthermore took an established point-of-care test system a step further and analyzed disposable test fields for blood glucose monitoring also for Flowprobe-based acetaminophen screening without additional sample preparation. Using as little as 2 μL blood, the method had an LOD of 1 μg mL(-1) (coefficient of variation of ≤15%) and acetaminophen recoveries of 82 to 119% for blinded samples, as assessed by LC-MS/MS. Half an hour after ingestions of a single 1000 mg acetaminophen dose, indistinguishable drug levels were measured in three healthy volunteers by LC-MS/MS and Flowprobe-Orbitrap MS analysis of DBS. Flowprobe analysis of DBS was 6- to 100-times more sensitive than corresponding desorption electrospray ionization MS analysis for four drugs. For instance, the LOD for salicylic acid analysis was 0.07 ng mL(-1) with Flowprobe measurement. Furthermore, we showed that multi-component analysis of five different substances, which may mimic polypharmacy in diabetes patients, in one blood sample for screening purposes was feasible. Taken together, our study suggests that microjunction surface sampling of DBS on filter paper and disposable point-of-care test fields may be developed into routine methods for near-patient multi-compound therapeutic drug monitoring that may advance blood screening analysis for patients with polypharmacy." @default.
• W2226452986 created "2016-06-24" @default.
• W2226452986 creator A5018292264 @default.
• W2226452986 creator A5024412155 @default.
• W2226452986 creator A5035115026 @default.
• W2226452986 creator A5062905648 @default.
• W2226452986 creator A5089376976 @default.
• W2226452986 date "2016-01-01" @default.
• W2226452986 modified "2023-09-27" @default.
• W2226452986 title "Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry" @default.
• W2226452986 cites W142603388 @default.
• W2226452986 cites W1515542254 @default.
• W2226452986 cites W1578639372 @default.
• W2226452986 cites W1902491637 @default.
• W2226452986 cites W1969926320 @default.
• W2226452986 cites W1983487928 @default.
• W2226452986 cites W2002533466 @default.
• W2226452986 cites W2004205323 @default.
• W2226452986 cites W2005703017 @default.
• W2226452986 cites W2008839228 @default.
• W2226452986 cites W2008998024 @default.
• W2226452986 cites W2014556601 @default.
• W2226452986 cites W2021324729 @default.
• W2226452986 cites W2027555357 @default.
• W2226452986 cites W2035212554 @default.
• W2226452986 cites W2042516926 @default.
• W2226452986 cites W2049603788 @default.
• W2226452986 cites W2054032039 @default.
• W2226452986 cites W2054855334 @default.
• W2226452986 cites W2060121473 @default.
• W2226452986 cites W2067570070 @default.
• W2226452986 cites W2079935519 @default.
• W2226452986 cites W2098458611 @default.
• W2226452986 cites W2103074008 @default.
• W2226452986 cites W2112618213 @default.
• W2226452986 cites W2121171062 @default.
• W2226452986 cites W2144660367 @default.
• W2226452986 cites W2147320720 @default.
• W2226452986 cites W2150040586 @default.
• W2226452986 cites W2163749141 @default.
• W2226452986 cites W2163790438 @default.
• W2226452986 cites W2178116036 @default.
• W2226452986 cites W2398833813 @default.
• W2226452986 cites W861722443 @default.
• W2226452986 doi "https://doi.org/10.1039/c5an02302e" @default.
• W2226452986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26759833" @default.
• W2226452986 hasPublicationYear "2016" @default.
• W2226452986 type Work @default.
• W2226452986 sameAs 2226452986 @default.
• W2226452986 citedByCount "26" @default.
• W2226452986 countsByYear W22264529862016 @default.
• W2226452986 countsByYear W22264529862017 @default.
• W2226452986 countsByYear W22264529862018 @default.
• W2226452986 countsByYear W22264529862019 @default.
• W2226452986 countsByYear W22264529862020 @default.
• W2226452986 countsByYear W22264529862021 @default.
• W2226452986 countsByYear W22264529862022 @default.
• W2226452986 countsByYear W22264529862023 @default.
• W2226452986 crossrefType "journal-article" @default.
• W2226452986 hasAuthorship W2226452986A5018292264 @default.
• W2226452986 hasAuthorship W2226452986A5024412155 @default.
• W2226452986 hasAuthorship W2226452986A5035115026 @default.
• W2226452986 hasAuthorship W2226452986A5062905648 @default.
• W2226452986 hasAuthorship W2226452986A5089376976 @default.
• W2226452986 hasBestOaLocation W22264529861 @default.
• W2226452986 hasConcept C118663420 @default.
• W2226452986 hasConcept C141071460 @default.
• W2226452986 hasConcept C145148216 @default.
• W2226452986 hasConcept C1621761 @default.
• W2226452986 hasConcept C162356407 @default.
• W2226452986 hasConcept C178790620 @default.
• W2226452986 hasConcept C185592680 @default.
• W2226452986 hasConcept C198291218 @default.
• W2226452986 hasConcept C205759337 @default.
• W2226452986 hasConcept C2776597655 @default.
• W2226452986 hasConcept C2778576202 @default.
• W2226452986 hasConcept C2780035454 @default.
• W2226452986 hasConcept C2780272996 @default.
• W2226452986 hasConcept C2780841973 @default.
• W2226452986 hasConcept C3017516299 @default.
• W2226452986 hasConcept C43617362 @default.
• W2226452986 hasConcept C64489805 @default.
• W2226452986 hasConcept C71924100 @default.
• W2226452986 hasConcept C98274493 @default.
• W2226452986 hasConceptScore W2226452986C118663420 @default.
• W2226452986 hasConceptScore W2226452986C141071460 @default.
• W2226452986 hasConceptScore W2226452986C145148216 @default.
• W2226452986 hasConceptScore W2226452986C1621761 @default.
• W2226452986 hasConceptScore W2226452986C162356407 @default.
• W2226452986 hasConceptScore W2226452986C178790620 @default.
• W2226452986 hasConceptScore W2226452986C185592680 @default.
• W2226452986 hasConceptScore W2226452986C198291218 @default.
• W2226452986 hasConceptScore W2226452986C205759337 @default.
• W2226452986 hasConceptScore W2226452986C2776597655 @default.
• W2226452986 hasConceptScore W2226452986C2778576202 @default.
• W2226452986 hasConceptScore W2226452986C2780035454 @default.
• W2226452986 hasConceptScore W2226452986C2780272996 @default.
• W2226452986 hasConceptScore W2226452986C2780841973 @default.

• next