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- W2226479932 abstract "Objective To explore the regulatory effects of exogenous adenosine on the excitability of stellate neurons and pyramidal neurons in the superficial layers of rats’ entorhinal cortex(EC) by using whole-cell patch-clamp recording technique.Methods Sample of superficial layers of entorhinal cortex(EC) was prepared.The morphology and location of stellate neurons and pyramidal neurons were visually identified using infrared differential interference contrast microscope.Following giga-seal formation and subsequent rupture of an electrically isolated patch of membrane for whole-cell configuration,the electrophysiological features of stellate neurons and pyramidal neurons were recorded,and the effects of adenosine(100μmol/L) on the excitability of these 2 types of neurons were examined.Meanwhile,the adenosine receptors interacting with these neurons were identified.Results Under voltage clamp,adenosine obviously inhibited the firing activity of stellate neurons and pyramidal neurons,though exhibiting no difference between the two types of neurons(P > 0.05).The inhibitory effect was blocked by DPCPX(3μmol/L),a selective A1 receptor antagonist,but not by DMPX(10μmol/L),a selective A2 receptor antagonist.Conclusion Adenosine may inhibit the firing activity of stellate neurons and pyramidal neurons in the superficial layers of the EC with the aid of A1 receptors." @default.
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- W2226479932 date "2011-09-01" @default.
- W2226479932 modified "2023-09-23" @default.
- W2226479932 title "Effects of adenosine on electric discharge of principal neurons in superficial layers of entorhinal cortex of rats" @default.
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