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- W2226560286 abstract "The B-cell receptor signaling pathway is integral to the pathogenesis of most B-cell malignancies, including chronic lymphocytic leukemia (CLL). One potential target in that pathway is Bruton tyrosine kinase (BTK). Acalabrutinib (ACP-196), an irreversible BTK inhibitor, lacks much of the “off-target” binding of the first-in-class agent, ibrutinib.Investigators conducted a manufacturer-funded, uncontrolled trial of …" @default.
- W2226560286 created "2016-06-24" @default.
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- W2226560286 date "2016-01-08" @default.
- W2226560286 modified "2023-09-28" @default.
- W2226560286 title "A Second-Generation BTK Inhibitor for Chronic Lymphocytic Leukemia" @default.
- W2226560286 doi "https://doi.org/10.1056/nejm-jw.na39945" @default.
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