Matches in SemOpenAlex for { <https://semopenalex.org/work/W2226571003> ?p ?o ?g. }
- W2226571003 endingPage "214" @default.
- W2226571003 startingPage "202" @default.
- W2226571003 abstract "Chronic stress significantly affects neuron morphometry and function in the prefrontal cortex, a brain region controlling cognition and emotion. However, whether and how chronic stress regulates the maturation of NG2-expressing oligodendrocyte precursor cell (NG2+ cell) and the importance of these changes remained unknown. Here, we report that exposing adult mice to chronic stress results in NG2+ cell atrophy and myelination arrested in the medial prefrontal cortex (mPFC), and impaired mPFC-dependent functions. These alterations, are phenocopied by overexpression of death receptor 6 (DR6) in NG2+ cell. Conversely, selectively silencing of DR6 in the NG2+ cell can partly rescue NG2+ cell atrophy and cognitive deficiency caused by chronic stress. We further demonstrate that myelination appears necessary for mPFC-dependent cognitive processes, as lysolecithin (LPC)-induced demyelination specifically in the mPFC is sufficient to cause these behavioral and cognitive impairments. Our results indicate that chronic stress impairs cognitive functions, at least in part, through modulation of NG2+ cell maturation and myelination, and suggest that myelination is require for normal cognitive functions." @default.
- W2226571003 created "2016-06-24" @default.
- W2226571003 creator A5009478901 @default.
- W2226571003 creator A5020554965 @default.
- W2226571003 creator A5036157514 @default.
- W2226571003 creator A5050986123 @default.
- W2226571003 date "2016-03-01" @default.
- W2226571003 modified "2023-09-24" @default.
- W2226571003 title "Chronic stress regulates NG2+ cell maturation and myelination in the prefrontal cortex through induction of death receptor 6" @default.
- W2226571003 cites W1561431666 @default.
- W2226571003 cites W1576796286 @default.
- W2226571003 cites W1578905184 @default.
- W2226571003 cites W1649032905 @default.
- W2226571003 cites W1815520451 @default.
- W2226571003 cites W1966347912 @default.
- W2226571003 cites W1967937854 @default.
- W2226571003 cites W1971006243 @default.
- W2226571003 cites W1979552960 @default.
- W2226571003 cites W1980230515 @default.
- W2226571003 cites W1995185151 @default.
- W2226571003 cites W1997221050 @default.
- W2226571003 cites W2001188679 @default.
- W2226571003 cites W2011764575 @default.
- W2226571003 cites W2013030103 @default.
- W2226571003 cites W2031106541 @default.
- W2226571003 cites W2033543553 @default.
- W2226571003 cites W2037060258 @default.
- W2226571003 cites W2038114873 @default.
- W2226571003 cites W2044216636 @default.
- W2226571003 cites W2045855955 @default.
- W2226571003 cites W2048082433 @default.
- W2226571003 cites W2050659319 @default.
- W2226571003 cites W2052460692 @default.
- W2226571003 cites W2053632281 @default.
- W2226571003 cites W2058467798 @default.
- W2226571003 cites W2058915525 @default.
- W2226571003 cites W2059276463 @default.
- W2226571003 cites W2065617967 @default.
- W2226571003 cites W2065770359 @default.
- W2226571003 cites W2070005343 @default.
- W2226571003 cites W2071256705 @default.
- W2226571003 cites W2073192094 @default.
- W2226571003 cites W2073699108 @default.
- W2226571003 cites W2074926091 @default.
- W2226571003 cites W2079246150 @default.
- W2226571003 cites W2082117755 @default.
- W2226571003 cites W2083536525 @default.
- W2226571003 cites W2084207424 @default.
- W2226571003 cites W2085529478 @default.
- W2226571003 cites W2087404956 @default.
- W2226571003 cites W2089127919 @default.
- W2226571003 cites W2096222626 @default.
- W2226571003 cites W2102178526 @default.
- W2226571003 cites W2110309782 @default.
- W2226571003 cites W2115585096 @default.
- W2226571003 cites W2117029190 @default.
- W2226571003 cites W2123556420 @default.
- W2226571003 cites W2138887185 @default.
- W2226571003 cites W2143044967 @default.
- W2226571003 cites W2148245899 @default.
- W2226571003 cites W2152739686 @default.
- W2226571003 cites W2154163783 @default.
- W2226571003 cites W2157257192 @default.
- W2226571003 cites W2158631116 @default.
- W2226571003 cites W2158874834 @default.
- W2226571003 cites W2160383565 @default.
- W2226571003 cites W2161775276 @default.
- W2226571003 cites W2162459454 @default.
- W2226571003 cites W2176978669 @default.
- W2226571003 cites W652855793 @default.
- W2226571003 doi "https://doi.org/10.1016/j.expneurol.2016.01.003" @default.
- W2226571003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26772637" @default.
- W2226571003 hasPublicationYear "2016" @default.
- W2226571003 type Work @default.
- W2226571003 sameAs 2226571003 @default.
- W2226571003 citedByCount "29" @default.
- W2226571003 countsByYear W22265710032016 @default.
- W2226571003 countsByYear W22265710032017 @default.
- W2226571003 countsByYear W22265710032018 @default.
- W2226571003 countsByYear W22265710032019 @default.
- W2226571003 countsByYear W22265710032020 @default.
- W2226571003 countsByYear W22265710032021 @default.
- W2226571003 countsByYear W22265710032022 @default.
- W2226571003 countsByYear W22265710032023 @default.
- W2226571003 crossrefType "journal-article" @default.
- W2226571003 hasAuthorship W2226571003A5009478901 @default.
- W2226571003 hasAuthorship W2226571003A5020554965 @default.
- W2226571003 hasAuthorship W2226571003A5036157514 @default.
- W2226571003 hasAuthorship W2226571003A5050986123 @default.
- W2226571003 hasConcept C1491633281 @default.
- W2226571003 hasConcept C15744967 @default.
- W2226571003 hasConcept C169760540 @default.
- W2226571003 hasConcept C169900460 @default.
- W2226571003 hasConcept C190283241 @default.
- W2226571003 hasConcept C2778654844 @default.
- W2226571003 hasConcept C2781172350 @default.
- W2226571003 hasConcept C2781195155 @default.
- W2226571003 hasConcept C31573885 @default.