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- W22266373 endingPage "65" @default.
- W22266373 startingPage "41" @default.
- W22266373 abstract "Measurement of serum drug concentration may be misleading for a strongly protein-bound drug because a drug bound to protein is inactive and only unbound or free drug is pharmacologically active. Although free drug concentration can be estimated from total concentration in most cases, under certain pathophysiological conditions such as uremia, liver disease, and hypoalbuminemia free drug concentration may be significantly elevated even if the concentration of the total drug is within therapeutic range. Drug–drug interactions may also lead to a disproportionate increase in free drug concentrations. Elderly patients usually show increased free drug concentrations because of hypoalbuminemia. Elevated free phenytoin concentrations have also been reported in patients with AIDS and pregnancy. Currently, free drug concentrations of anticonvulsants such as phenytoin, carbamazepine, and valproic acid are widely measured in clinical laboratories. Newer drugs such as mycophenolic acid mofetil and certain protease inhibitors are also considered as candidates for monitoring free drug concentration." @default.
- W22266373 created "2016-06-24" @default.
- W22266373 creator A5055039506 @default.
- W22266373 date "2007-10-04" @default.
- W22266373 modified "2023-09-26" @default.
- W22266373 title "Monitoring Free Drug Concentration" @default.
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