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- W2226731898 abstract "Large randomized controlled trials have found that in non-valvular atrial fibrillation (AF), non-vitamin K antagonist oral anticoagulants (NOACs) had a favorable risk–benefit profile, with significant reductions in stroke, mortality and intracranial hemorrhage, but possibly increased gastrointestinal bleeding [ [1] Ruff C.T. Giugliano R.P. Braunwald E. Hoffman E.B. Deenadayalu N. Ezekowitz M.D. et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014; 383: 955-962 Abstract Full Text Full Text PDF PubMed Scopus (3216) Google Scholar ]. After the approval of dabigatran, many agencies in different countries received reports of severe dabigatran related bleeding reports through their adverse event reporting system. Concurrently, several case reports of dabigatran induced bleeding were published in medical journals and discussed in the mainstream media. The comparative safety of dabigatran vs adjusted-dose vitamin K antagonist (VKA) (INR 2–3) for treatment of AF in routine care settings is thus a matter of debate in several countries and may affect the level of reimbursement. Therefore, we performed a meta-analysis of observational studies available evaluating the treatment effect of dabigatran compared with VKA in AF, specifically those in which an adjusted or matched analysis on baseline characteristics was available." @default.
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- W2226731898 date "2016-03-01" @default.
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- W2226731898 title "Bleeding risk in patients treated with dabigatran or vitamin K antagonist for atrial fibrillation: A meta analysis of adjusted analysis in routine practice settings" @default.
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- W2226731898 doi "https://doi.org/10.1016/j.ijcard.2016.01.065" @default.
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