Matches in SemOpenAlex for { <https://semopenalex.org/work/W22267714> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W22267714 endingPage "37" @default.
- W22267714 startingPage "128" @default.
- W22267714 abstract "In the perfused isolated central ear artery of the rabbit, nicotine, acetylcholine (ACh), tetramethylammonium (TMA) and carbachol (CCh) at high concentrations (greater than 1 mug/ml) produced transient vasoconstriction. The order of potency was: nicotine greater than ACh greater than TMA greater than CCh. Over the concentration range used, all of the agonists except ACh gave bell-shaped log concentration-response curves. Methacholine did not cause vasoconstriction. The response to ACh, TMA or CCh, but not to nicotine, was potentiated by atropine (0.1-1.0 mug/ml). Tetraethylammonium, hexamethonium, mecamylamine and d-tubocurarine blocked the response to the nicotinic agonists and to nerve stimulation. Ear arteries from reserpine-treated rabbits gave no, or very little, constrictor response to the nicotinic agonists or to nerve stimulation. These findings support the conclusion that the vasoconstriction produced by the nicotinic agonists is mediated by norepinephrine released from adrenergic nerve terminals as a result of the action of the agents on neuronal nicotinic receptors located at or near the terminals. The potentiation by atropine of the constrictor response to ACh, TMA and CCh is attributed to the blockade by atropine of neuronal muscarinic receptors on which these agonists act to inhibit the release of norepinephrine." @default.
- W22267714 created "2016-06-24" @default.
- W22267714 creator A5010310471 @default.
- W22267714 creator A5012662410 @default.
- W22267714 date "1975-04-01" @default.
- W22267714 modified "2023-09-23" @default.
- W22267714 title "Vasoconstriction of the isolated rabbit ear artery caused by nicotinic agonists acting on adrenergic neurons." @default.
- W22267714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/237110" @default.
- W22267714 hasPublicationYear "1975" @default.
- W22267714 type Work @default.
- W22267714 sameAs 22267714 @default.
- W22267714 citedByCount "18" @default.
- W22267714 countsByYear W222677142016 @default.
- W22267714 crossrefType "journal-article" @default.
- W22267714 hasAuthorship W22267714A5010310471 @default.
- W22267714 hasAuthorship W22267714A5012662410 @default.
- W22267714 hasConcept C126322002 @default.
- W22267714 hasConcept C134018914 @default.
- W22267714 hasConcept C170493617 @default.
- W22267714 hasConcept C185592680 @default.
- W22267714 hasConcept C188987157 @default.
- W22267714 hasConcept C24998067 @default.
- W22267714 hasConcept C2775859210 @default.
- W22267714 hasConcept C2775893369 @default.
- W22267714 hasConcept C2775910092 @default.
- W22267714 hasConcept C2776880047 @default.
- W22267714 hasConcept C2778988552 @default.
- W22267714 hasConcept C2779961880 @default.
- W22267714 hasConcept C33789571 @default.
- W22267714 hasConcept C55493867 @default.
- W22267714 hasConcept C71924100 @default.
- W22267714 hasConcept C98274493 @default.
- W22267714 hasConceptScore W22267714C126322002 @default.
- W22267714 hasConceptScore W22267714C134018914 @default.
- W22267714 hasConceptScore W22267714C170493617 @default.
- W22267714 hasConceptScore W22267714C185592680 @default.
- W22267714 hasConceptScore W22267714C188987157 @default.
- W22267714 hasConceptScore W22267714C24998067 @default.
- W22267714 hasConceptScore W22267714C2775859210 @default.
- W22267714 hasConceptScore W22267714C2775893369 @default.
- W22267714 hasConceptScore W22267714C2775910092 @default.
- W22267714 hasConceptScore W22267714C2776880047 @default.
- W22267714 hasConceptScore W22267714C2778988552 @default.
- W22267714 hasConceptScore W22267714C2779961880 @default.
- W22267714 hasConceptScore W22267714C33789571 @default.
- W22267714 hasConceptScore W22267714C55493867 @default.
- W22267714 hasConceptScore W22267714C71924100 @default.
- W22267714 hasConceptScore W22267714C98274493 @default.
- W22267714 hasIssue "1" @default.
- W22267714 hasLocation W222677141 @default.
- W22267714 hasOpenAccess W22267714 @default.
- W22267714 hasPrimaryLocation W222677141 @default.
- W22267714 hasRelatedWork W1914383463 @default.
- W22267714 hasRelatedWork W1975576325 @default.
- W22267714 hasRelatedWork W2009496653 @default.
- W22267714 hasRelatedWork W2072895524 @default.
- W22267714 hasRelatedWork W2075048436 @default.
- W22267714 hasRelatedWork W2077188107 @default.
- W22267714 hasRelatedWork W2081132930 @default.
- W22267714 hasRelatedWork W22267714 @default.
- W22267714 hasRelatedWork W2415209620 @default.
- W22267714 hasRelatedWork W2133120054 @default.
- W22267714 hasVolume "193" @default.
- W22267714 isParatext "false" @default.
- W22267714 isRetracted "false" @default.
- W22267714 magId "22267714" @default.
- W22267714 workType "article" @default.