FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2226961567> ?p ?o ?g. }

• W2226961567 endingPage "99" @default.
• W2226961567 startingPage "89" @default.
• W2226961567 abstract "The functional properties of myeloid dendritic cells (DCs) differ, depending on microenvironmental factors as well as on their stage of maturation. The main approaches for the selective enhancement of the tolerogenic properties of DCs include the induction of a pharmacological arrest of the DCs maturation and the genetical engineering of DCs expressing immunosuppressive molecules. Several immunosuppressive/anti-inflammatory agents have been discovered that potentially inhibit DC maturation and immunogenicity. Photopheresis (ECP) is an immunomodulatory therapy in which leucocytes are exposed to 8-methoxypsoralen (8-MOP) and ultraviolet (UV) A radiation (PUVA). The combination of ECP with immunosuppressive agents has demonstrated efficacy in the management of transplanted patients by reducing either the incidence of organ rejection or the pharmacological toxicity. In particular, we have observed in hepatitis C virus (HCV)-positive patients that the same combination has reduced the immunosuppressive burden and improved sustainability and efficacy of pre-emptive antiviral therapy after liver transplantation. Therefore, in our work we investigated the in vitro effects of PUVA, combined with immunosuppressive drugs (IDs), on both in vitro human DC generation and maturation, in order to contribute to understanding the immunological mechanisms underlying this pharmacological combination. Monocyte PUVA-treatment was performed by using an in vitro experimental protocol that we previously described. PUVA-treated or -untreated highly purified CD14+ cells were incubated with the association of the immunosuppressive drugs, used in the management of liver transplantation, at two different concentrations, in the presence of IL-4 and GM-CSF. The treatment with IDs at the highest concentration (corresponding to that used in clinical practice), alone or in association with PUVA, induced an immunosuppressive effect, by impairing both DC generation and maturation. Neither immunosuppressive drugs at the lowest concentration nor their combination with PUVA affected myeloid DC generation, but modified DC functions, strengthening the induction of a tolerogenic pattern. As this ID concentration was arbitrarily chosen, further experiments could highlight whether lower concentrations than those used in clinical practice would elicit the same effect on DCs and potentially improve their functional properties. This work describes an original experimental approach exploring the in vitro mechanism of action of the combined procedure of PUVA with immunosuppressive drugs, used in liver transplantation, on DCs generation and function. Our results contribute to the knowledge of the mechanisms of action of this combined procedure on DCs, suggesting useful therapeutic implications for the in vivo therapy." @default.
• W2226961567 created "2016-06-24" @default.
• W2226961567 creator A5001209743 @default.
• W2226961567 creator A5055437954 @default.
• W2226961567 creator A5059999020 @default.
• W2226961567 creator A5072567218 @default.
• W2226961567 creator A5074096990 @default.
• W2226961567 creator A5077066081 @default.
• W2226961567 creator A5079502589 @default.
• W2226961567 date "2011-01-01" @default.
• W2226961567 modified "2023-10-18" @default.
• W2226961567 title "The Combination of Immunosuppressive Drugs with 8-Methoxypsoralen and Ultraviolet a Light Modulates the Myeloid-Derived Dendritic Cell Function" @default.
• W2226961567 cites W1510116615 @default.
• W2226961567 cites W1535196380 @default.
• W2226961567 cites W1601096994 @default.
• W2226961567 cites W1675113161 @default.
• W2226961567 cites W1973876618 @default.
• W2226961567 cites W1982390046 @default.
• W2226961567 cites W1985138302 @default.
• W2226961567 cites W1993333427 @default.
• W2226961567 cites W1995801129 @default.
• W2226961567 cites W1997985543 @default.
• W2226961567 cites W2006075845 @default.
• W2226961567 cites W2008792570 @default.
• W2226961567 cites W2028007100 @default.
• W2226961567 cites W2039436354 @default.
• W2226961567 cites W2040941306 @default.
• W2226961567 cites W2042106673 @default.
• W2226961567 cites W2044406822 @default.
• W2226961567 cites W2057917442 @default.
• W2226961567 cites W2060480078 @default.
• W2226961567 cites W2062512887 @default.
• W2226961567 cites W2065244027 @default.
• W2226961567 cites W2067858629 @default.
• W2226961567 cites W2073498442 @default.
• W2226961567 cites W2088127225 @default.
• W2226961567 cites W2090623727 @default.
• W2226961567 cites W2093332059 @default.
• W2226961567 cites W2116493118 @default.
• W2226961567 cites W2127876789 @default.
• W2226961567 cites W2143266015 @default.
• W2226961567 cites W2161240946 @default.
• W2226961567 cites W2253492562 @default.
• W2226961567 cites W2316405448 @default.
• W2226961567 cites W325332095 @default.
• W2226961567 cites W4313149377 @default.
• W2226961567 doi "https://doi.org/10.1177/039463201102400111" @default.
• W2226961567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21496391" @default.
• W2226961567 hasPublicationYear "2011" @default.
• W2226961567 type Work @default.
• W2226961567 sameAs 2226961567 @default.
• W2226961567 citedByCount "7" @default.
• W2226961567 countsByYear W22269615672012 @default.
• W2226961567 countsByYear W22269615672013 @default.
• W2226961567 countsByYear W22269615672019 @default.
• W2226961567 countsByYear W22269615672022 @default.
• W2226961567 crossrefType "journal-article" @default.
• W2226961567 hasAuthorship W2226961567A5001209743 @default.
• W2226961567 hasAuthorship W2226961567A5055437954 @default.
• W2226961567 hasAuthorship W2226961567A5059999020 @default.
• W2226961567 hasAuthorship W2226961567A5072567218 @default.
• W2226961567 hasAuthorship W2226961567A5074096990 @default.
• W2226961567 hasAuthorship W2226961567A5077066081 @default.
• W2226961567 hasAuthorship W2226961567A5079502589 @default.
• W2226961567 hasConcept C141071460 @default.
• W2226961567 hasConcept C203014093 @default.
• W2226961567 hasConcept C2778170410 @default.
• W2226961567 hasConcept C2779282312 @default.
• W2226961567 hasConcept C2911091166 @default.
• W2226961567 hasConcept C502942594 @default.
• W2226961567 hasConcept C71924100 @default.
• W2226961567 hasConcept C8891405 @default.
• W2226961567 hasConcept C98274493 @default.
• W2226961567 hasConceptScore W2226961567C141071460 @default.
• W2226961567 hasConceptScore W2226961567C203014093 @default.
• W2226961567 hasConceptScore W2226961567C2778170410 @default.
• W2226961567 hasConceptScore W2226961567C2779282312 @default.
• W2226961567 hasConceptScore W2226961567C2911091166 @default.
• W2226961567 hasConceptScore W2226961567C502942594 @default.
• W2226961567 hasConceptScore W2226961567C71924100 @default.
• W2226961567 hasConceptScore W2226961567C8891405 @default.
• W2226961567 hasConceptScore W2226961567C98274493 @default.
• W2226961567 hasIssue "1" @default.
• W2226961567 hasLocation W22269615671 @default.
• W2226961567 hasLocation W22269615672 @default.
• W2226961567 hasOpenAccess W2226961567 @default.
• W2226961567 hasPrimaryLocation W22269615671 @default.
• W2226961567 hasRelatedWork W1970396987 @default.
• W2226961567 hasRelatedWork W1993894494 @default.
• W2226961567 hasRelatedWork W2007093250 @default.
• W2226961567 hasRelatedWork W2095840099 @default.
• W2226961567 hasRelatedWork W2097621356 @default.
• W2226961567 hasRelatedWork W2142583764 @default.
• W2226961567 hasRelatedWork W2169997919 @default.
• W2226961567 hasRelatedWork W2375999619 @default.
• W2226961567 hasRelatedWork W2591227656 @default.
• W2226961567 hasRelatedWork W3028918594 @default.
• W2226961567 hasVolume "24" @default.

• next