Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227122418> ?p ?o ?g. }
- W2227122418 abstract "Dysregulation of Hedgehog (Hh) signaling pathway has been documented in mammary gland development and breast cancer (BC) progression. Despite the remarkable progress in therapeutic interventions, BC related mortality in Bangladesh increased in the last decade. Triple negative breast cancer (TNBC) still presents a critical therapeutic challenge. Thus effective targeted therapy is urgently needed. In this study, we report the clinicopathological characteristics and prognosis of BC patients from Bangladesh. Routine immunohistochemical analysis and high throughput RNA-Seq data from the TCGA library were used to analyze the expression pattern and association of high and low level of Shh expression in a collection of BC patients with a long-term follow-up. High levels of Shh were observed in a subset of BC tumors with poor prognostic pathological features. Higher level of Shh expression correlated with a significantly poorer overall survival of patients compared with patients whose tumors expressed a low level of Shh. These data support the contention that Shh could be a novel biomarker for breast cancer that is involved in mediating the aggressive phenotype of BC. We propose that BC patients exhibiting a higher level of Shh expression, representing a subset of BC patients, would be amenable to Shh targeted therapy." @default.
- W2227122418 created "2016-06-24" @default.
- W2227122418 creator A5016707957 @default.
- W2227122418 creator A5019566845 @default.
- W2227122418 creator A5024164153 @default.
- W2227122418 creator A5027854700 @default.
- W2227122418 creator A5030913571 @default.
- W2227122418 creator A5035887525 @default.
- W2227122418 creator A5037851493 @default.
- W2227122418 creator A5038471270 @default.
- W2227122418 creator A5038975262 @default.
- W2227122418 creator A5048975213 @default.
- W2227122418 creator A5049914982 @default.
- W2227122418 creator A5052573526 @default.
- W2227122418 creator A5053674227 @default.
- W2227122418 creator A5070710430 @default.
- W2227122418 creator A5071351400 @default.
- W2227122418 creator A5084153701 @default.
- W2227122418 creator A5090356906 @default.
- W2227122418 date "2016-01-05" @default.
- W2227122418 modified "2023-10-16" @default.
- W2227122418 title "Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh" @default.
- W2227122418 cites W1036700926 @default.
- W2227122418 cites W1759742290 @default.
- W2227122418 cites W1975104394 @default.
- W2227122418 cites W1995224853 @default.
- W2227122418 cites W1997889647 @default.
- W2227122418 cites W2001331741 @default.
- W2227122418 cites W2025011676 @default.
- W2227122418 cites W2039795381 @default.
- W2227122418 cites W2045569268 @default.
- W2227122418 cites W2050841232 @default.
- W2227122418 cites W2053996795 @default.
- W2227122418 cites W2068698074 @default.
- W2227122418 cites W2070632651 @default.
- W2227122418 cites W2073534521 @default.
- W2227122418 cites W2073950181 @default.
- W2227122418 cites W2085860699 @default.
- W2227122418 cites W2091519635 @default.
- W2227122418 cites W2097795514 @default.
- W2227122418 cites W2107394975 @default.
- W2227122418 cites W2109997465 @default.
- W2227122418 cites W2114471035 @default.
- W2227122418 cites W2120064337 @default.
- W2227122418 cites W2125744935 @default.
- W2227122418 cites W2128473328 @default.
- W2227122418 cites W2142243714 @default.
- W2227122418 cites W2146905485 @default.
- W2227122418 cites W2154431984 @default.
- W2227122418 cites W2156151160 @default.
- W2227122418 cites W2161426850 @default.
- W2227122418 cites W2164461552 @default.
- W2227122418 cites W2313934125 @default.
- W2227122418 cites W44957457 @default.
- W2227122418 doi "https://doi.org/10.1038/srep18830" @default.
- W2227122418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4700415" @default.
- W2227122418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26727947" @default.
- W2227122418 hasPublicationYear "2016" @default.
- W2227122418 type Work @default.
- W2227122418 sameAs 2227122418 @default.
- W2227122418 citedByCount "49" @default.
- W2227122418 countsByYear W22271224182016 @default.
- W2227122418 countsByYear W22271224182017 @default.
- W2227122418 countsByYear W22271224182018 @default.
- W2227122418 countsByYear W22271224182019 @default.
- W2227122418 countsByYear W22271224182020 @default.
- W2227122418 countsByYear W22271224182021 @default.
- W2227122418 countsByYear W22271224182022 @default.
- W2227122418 countsByYear W22271224182023 @default.
- W2227122418 crossrefType "journal-article" @default.
- W2227122418 hasAuthorship W2227122418A5016707957 @default.
- W2227122418 hasAuthorship W2227122418A5019566845 @default.
- W2227122418 hasAuthorship W2227122418A5024164153 @default.
- W2227122418 hasAuthorship W2227122418A5027854700 @default.
- W2227122418 hasAuthorship W2227122418A5030913571 @default.
- W2227122418 hasAuthorship W2227122418A5035887525 @default.
- W2227122418 hasAuthorship W2227122418A5037851493 @default.
- W2227122418 hasAuthorship W2227122418A5038471270 @default.
- W2227122418 hasAuthorship W2227122418A5038975262 @default.
- W2227122418 hasAuthorship W2227122418A5048975213 @default.
- W2227122418 hasAuthorship W2227122418A5049914982 @default.
- W2227122418 hasAuthorship W2227122418A5052573526 @default.
- W2227122418 hasAuthorship W2227122418A5053674227 @default.
- W2227122418 hasAuthorship W2227122418A5070710430 @default.
- W2227122418 hasAuthorship W2227122418A5071351400 @default.
- W2227122418 hasAuthorship W2227122418A5084153701 @default.
- W2227122418 hasAuthorship W2227122418A5090356906 @default.
- W2227122418 hasBestOaLocation W22271224181 @default.
- W2227122418 hasConcept C104317684 @default.
- W2227122418 hasConcept C121608353 @default.
- W2227122418 hasConcept C126322002 @default.
- W2227122418 hasConcept C127716648 @default.
- W2227122418 hasConcept C143998085 @default.
- W2227122418 hasConcept C204232928 @default.
- W2227122418 hasConcept C207886595 @default.
- W2227122418 hasConcept C2776637008 @default.
- W2227122418 hasConcept C2778539099 @default.
- W2227122418 hasConcept C2780110267 @default.
- W2227122418 hasConcept C2781197716 @default.
- W2227122418 hasConcept C502942594 @default.