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- W2227140814 abstract "High prevalence of obesity and the numerous negative health effects that are associated with this phenotype, it is relevant to examine the pathway of leptin in order to determine effective treatment options. The Ob gene, which is known to encode the 16 kDa protein hormone leptin, is one of the main genes that have been linked to the obesity phenotype in humans. Leptin is primarily synthesized and secreted by white adipose tissue and acts through a complex mechanism involving receptors in the brain and several peripheral tissues. Its plasma concentration varies in proportion to fat mass. Mutations of the leptin or leptin receptor gene are associated with obesity and insulin resistance. Leptin deficiency is a very rare in humans. In contrast, many obese humans have a high circulating leptin concentration, which apparently does not prevent the growth of their adipose tissue, suggesting that leptin resistance. Thus high prevalence of obesity and the numerous negative health effects that are associated with this phenotype, it is relevant to examine the pathway of leptin in order to determine effective treatment options. Binding of leptin to its receptors in the hypothalamus and brain stem coordinates the activity of neuroendocrine unit that inhibit food intake and increase energy expenditure, metabolism, neuroendocrine axis, and immune function. Loss of function mutations of the leptin or leptin receptor gene is associated with obesity and insulin resistance. Current treatment options, including both gene therapy and direct leptin injections have proven to be modestly successful." @default.
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- W2227140814 date "2016-01-01" @default.
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- W2227140814 title "Leptin Dysfunction: A Cause for Obesity." @default.
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