Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227163679> ?p ?o ?g. }
- W2227163679 endingPage "15" @default.
- W2227163679 startingPage "1" @default.
- W2227163679 abstract "The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth factor in the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative diseases. Investigation of disease-related changes in BDNF transport might provide insights into the cellular mechanism underlying, for example, Alzheimer’s disease (AD). To analyze the role of BDNF transport in AD, live cell imaging of fluorescently labeled BDNF was performed in hippocampal neurons of different AD model systems. BDNF and APP colocalized with low incidence in vesicular structures. Anterograde as well as retrograde transport of BDNF vesicles was reduced and these effects were mediated by factors released from hippocampal neurons into the extracellular medium. Transport of BDNF was altered at a very early time point after onset of human APP expression or after acute amyloid-beta(1-42) treatment, while the activity-dependent release of BDNF remained unaffected. Taken together, extracellular cleavage products of APP induced rapid changes in anterograde and retrograde transport of BDNF-containing vesicles while release of BDNF was unaffected by transgenic expression of mutated APP. These early transport deficits might lead to permanently impaired brain functions in the adult brain." @default.
- W2227163679 created "2016-06-24" @default.
- W2227163679 creator A5003213988 @default.
- W2227163679 creator A5016139193 @default.
- W2227163679 creator A5021432744 @default.
- W2227163679 creator A5023263973 @default.
- W2227163679 creator A5060864006 @default.
- W2227163679 creator A5067076261 @default.
- W2227163679 creator A5073636267 @default.
- W2227163679 creator A5075987309 @default.
- W2227163679 date "2016-01-01" @default.
- W2227163679 modified "2023-10-10" @default.
- W2227163679 title "Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons" @default.
- W2227163679 cites W1514231771 @default.
- W2227163679 cites W1516330077 @default.
- W2227163679 cites W1536527949 @default.
- W2227163679 cites W1540823632 @default.
- W2227163679 cites W1579070500 @default.
- W2227163679 cites W1595455317 @default.
- W2227163679 cites W1704187562 @default.
- W2227163679 cites W1832821166 @default.
- W2227163679 cites W1869318026 @default.
- W2227163679 cites W1966507933 @default.
- W2227163679 cites W1968900405 @default.
- W2227163679 cites W1969634414 @default.
- W2227163679 cites W1971402768 @default.
- W2227163679 cites W1971490023 @default.
- W2227163679 cites W1973883693 @default.
- W2227163679 cites W1974145718 @default.
- W2227163679 cites W1974723522 @default.
- W2227163679 cites W1976214262 @default.
- W2227163679 cites W1978119802 @default.
- W2227163679 cites W1981071608 @default.
- W2227163679 cites W1981218259 @default.
- W2227163679 cites W1981415432 @default.
- W2227163679 cites W1984603208 @default.
- W2227163679 cites W1984957488 @default.
- W2227163679 cites W1986977063 @default.
- W2227163679 cites W1987615735 @default.
- W2227163679 cites W1987809028 @default.
- W2227163679 cites W1988507091 @default.
- W2227163679 cites W1989133066 @default.
- W2227163679 cites W1989258392 @default.
- W2227163679 cites W1992970592 @default.
- W2227163679 cites W1996893328 @default.
- W2227163679 cites W2005128877 @default.
- W2227163679 cites W2006374396 @default.
- W2227163679 cites W2007389732 @default.
- W2227163679 cites W2011254357 @default.
- W2227163679 cites W2012887006 @default.
- W2227163679 cites W2014402388 @default.
- W2227163679 cites W2020460747 @default.
- W2227163679 cites W2022782971 @default.
- W2227163679 cites W2023317124 @default.
- W2227163679 cites W2025561374 @default.
- W2227163679 cites W2026538105 @default.
- W2227163679 cites W2029565457 @default.
- W2227163679 cites W2030771734 @default.
- W2227163679 cites W2034614968 @default.
- W2227163679 cites W2035415625 @default.
- W2227163679 cites W2037091801 @default.
- W2227163679 cites W2042567578 @default.
- W2227163679 cites W2045270516 @default.
- W2227163679 cites W2049692154 @default.
- W2227163679 cites W2056409809 @default.
- W2227163679 cites W2060446687 @default.
- W2227163679 cites W2065052232 @default.
- W2227163679 cites W2066386560 @default.
- W2227163679 cites W2075189940 @default.
- W2227163679 cites W2077464099 @default.
- W2227163679 cites W2077977333 @default.
- W2227163679 cites W2078291850 @default.
- W2227163679 cites W2080225612 @default.
- W2227163679 cites W2081678091 @default.
- W2227163679 cites W2082022687 @default.
- W2227163679 cites W2084973310 @default.
- W2227163679 cites W2085242832 @default.
- W2227163679 cites W2090012993 @default.
- W2227163679 cites W2092524511 @default.
- W2227163679 cites W2095086331 @default.
- W2227163679 cites W2095099413 @default.
- W2227163679 cites W2096464090 @default.
- W2227163679 cites W2096991927 @default.
- W2227163679 cites W2105981057 @default.
- W2227163679 cites W2107538476 @default.
- W2227163679 cites W2109309568 @default.
- W2227163679 cites W2117526022 @default.
- W2227163679 cites W2121204857 @default.
- W2227163679 cites W2122835512 @default.
- W2227163679 cites W2126402425 @default.
- W2227163679 cites W2126541199 @default.
- W2227163679 cites W2136409632 @default.
- W2227163679 cites W2139565721 @default.
- W2227163679 cites W2140470674 @default.
- W2227163679 cites W2142186280 @default.
- W2227163679 cites W2142522231 @default.
- W2227163679 cites W2145261214 @default.
- W2227163679 cites W2148437789 @default.