FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227168049> ?p ?o ?g. }

• W2227168049 endingPage "e010160" @default.
• W2227168049 startingPage "e010160" @default.
• W2227168049 abstract "<h3>Introduction</h3> The choice of a basal insulin regimen to manage type 1 diabetes mellitus (T1DM) may have different risks of adverse events and effectiveness, due to the difference in the effectiveness of these agents across patient characteristics (eg, baseline glycosylated haemoglobin; A1_C). Currently, there is a lack of high quality evidence to support the tailoring of insulin regimens according to an individual9s needs. The aim of this study is to update our previous systematic review and perform an individual patient data network meta-analysis (IPD-NMA) to evaluate the comparative safety and effectiveness of long-acting versus intermediate-acting insulin in different subgroups of patients with T1DM. <h3>Methods and analysis</h3> We will update our previous literature search from January 2013 onwards searching relevant electronic databases (eg, MEDLINE), as well as perform grey literature search through relevant society/association websites, and conference abstracts, and scan reference lists of the eligible studies. We will include randomised clinical trials of any duration examining long-acting versus intermediate-acting insulin preparations for adult patients with T1DM. We will focus on A1_C and severe hypoglycaemia outcomes. For each pairwise treatment comparison, we will combine all IPD from all studies in a single multilevel model, where each study is a different cluster. For a connected network of trials, we will perform an IPD-NMA to identify potential effect modifiers, and estimate the most effective and safe treatments for patients with different characteristics. If we are not successful in obtaining IPD for at least one study, we will include aggregated data (AD) abstracted from the included RCTs in our analysis, combining IPD and AD into a single model. We will report our results using the PRISMA-IPD statement. <h3>Ethics and dissemination</h3> The results of this systematic review and IPD-NMA will be of interest to stakeholders and will help in improving existing guideline recommendations. <h3>PROSPERO registry number</h3> CRD42015023511." @default.
• W2227168049 created "2016-06-24" @default.
• W2227168049 creator A5007761401 @default.
• W2227168049 creator A5015669760 @default.
• W2227168049 creator A5068789622 @default.
• W2227168049 creator A5072544703 @default.
• W2227168049 creator A5074901391 @default.
• W2227168049 creator A5078920087 @default.
• W2227168049 date "2015-12-01" @default.
• W2227168049 modified "2023-10-06" @default.
• W2227168049 title "Safety and effectiveness of long-acting versus intermediate-acting insulin for patients with type 1 diabetes: protocol for a systematic review and individual patient data network meta-analysis" @default.
• W2227168049 cites W179067283 @default.
• W2227168049 cites W1967385770 @default.
• W2227168049 cites W1973914781 @default.
• W2227168049 cites W2004474087 @default.
• W2227168049 cites W2005501262 @default.
• W2227168049 cites W2010699829 @default.
• W2227168049 cites W2016832451 @default.
• W2227168049 cites W2019439229 @default.
• W2227168049 cites W2025091395 @default.
• W2227168049 cites W2026890622 @default.
• W2227168049 cites W2037593179 @default.
• W2227168049 cites W2037620269 @default.
• W2227168049 cites W2042304363 @default.
• W2227168049 cites W2050118439 @default.
• W2227168049 cites W2051743518 @default.
• W2227168049 cites W2068745906 @default.
• W2227168049 cites W2074147400 @default.
• W2227168049 cites W2075046475 @default.
• W2227168049 cites W2084539330 @default.
• W2227168049 cites W2085803274 @default.
• W2227168049 cites W2089186633 @default.
• W2227168049 cites W2091808438 @default.
• W2227168049 cites W2092653445 @default.
• W2227168049 cites W2096883889 @default.
• W2227168049 cites W2097744101 @default.
• W2227168049 cites W2100950755 @default.
• W2227168049 cites W2102684459 @default.
• W2227168049 cites W2109051507 @default.
• W2227168049 cites W2113144077 @default.
• W2227168049 cites W2114756800 @default.
• W2227168049 cites W2120726242 @default.
• W2227168049 cites W2125776201 @default.
• W2227168049 cites W2129821518 @default.
• W2227168049 cites W2131701504 @default.
• W2227168049 cites W2140604743 @default.
• W2227168049 cites W2140699272 @default.
• W2227168049 cites W2151225337 @default.
• W2227168049 cites W2155798268 @default.
• W2227168049 cites W2168331993 @default.
• W2227168049 cites W2169205464 @default.
• W2227168049 cites W2172193326 @default.
• W2227168049 cites W2586645431 @default.
• W2227168049 doi "https://doi.org/10.1136/bmjopen-2015-010160" @default.
• W2227168049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4710824" @default.
• W2227168049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26719325" @default.
• W2227168049 hasPublicationYear "2015" @default.
• W2227168049 type Work @default.
• W2227168049 sameAs 2227168049 @default.
• W2227168049 citedByCount "5" @default.
• W2227168049 countsByYear W22271680492016 @default.
• W2227168049 countsByYear W22271680492019 @default.
• W2227168049 countsByYear W22271680492021 @default.
• W2227168049 countsByYear W22271680492022 @default.
• W2227168049 countsByYear W22271680492023 @default.
• W2227168049 crossrefType "journal-article" @default.
• W2227168049 hasAuthorship W2227168049A5007761401 @default.
• W2227168049 hasAuthorship W2227168049A5015669760 @default.
• W2227168049 hasAuthorship W2227168049A5068789622 @default.
• W2227168049 hasAuthorship W2227168049A5072544703 @default.
• W2227168049 hasAuthorship W2227168049A5074901391 @default.
• W2227168049 hasAuthorship W2227168049A5078920087 @default.
• W2227168049 hasBestOaLocation W22271680491 @default.
• W2227168049 hasConcept C126322002 @default.
• W2227168049 hasConcept C134018914 @default.
• W2227168049 hasConcept C142724271 @default.
• W2227168049 hasConcept C154945302 @default.
• W2227168049 hasConcept C17744445 @default.
• W2227168049 hasConcept C184898388 @default.
• W2227168049 hasConcept C189708586 @default.
• W2227168049 hasConcept C197934379 @default.
• W2227168049 hasConcept C199539241 @default.
• W2227168049 hasConcept C204787440 @default.
• W2227168049 hasConcept C2779473830 @default.
• W2227168049 hasConcept C2780385302 @default.
• W2227168049 hasConcept C2781232474 @default.
• W2227168049 hasConcept C2781413609 @default.
• W2227168049 hasConcept C41008148 @default.
• W2227168049 hasConcept C555293320 @default.
• W2227168049 hasConcept C71924100 @default.
• W2227168049 hasConcept C95190672 @default.
• W2227168049 hasConceptScore W2227168049C126322002 @default.
• W2227168049 hasConceptScore W2227168049C134018914 @default.
• W2227168049 hasConceptScore W2227168049C142724271 @default.
• W2227168049 hasConceptScore W2227168049C154945302 @default.
• W2227168049 hasConceptScore W2227168049C17744445 @default.
• W2227168049 hasConceptScore W2227168049C184898388 @default.
• W2227168049 hasConceptScore W2227168049C189708586 @default.

• next