FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227182487> ?p ?o ?g. }

• W2227182487 endingPage "121" @default.
• W2227182487 startingPage "112" @default.
• W2227182487 abstract "Malignant melanoma is an aggressive form of skin cancer. Recently, drug therapy of advanced disease has been revolutionized by new agents. More therapeutic options, coupled with the desire to extend treatment to the adjuvant setting mean that prognostic biomarkers that can be assayed from formalin-fixed paraffin-embedded clinical would be valuable. microRNAs have potential to fill this need. We analyzed 377 microRNAs in 79 primary melanomas and 32 metastases using a split sample discovery strategy. From a discovery analysis using 40 thick primary melanomas (20 cases with metastasis and 20 controls without metastasis at 5 years), microRNA expression was measured by quantitative RT-PCR (QRT-PCR). MiR-10b emerged as a candidate prognostic microRNA. This was confirmed in an independent validation set of thick primary melanomas (20 cases with metastasis and 19 controls without metastasis at 5 years). In the combined discovery and validation cohorts (n=79), miR-10b expression showed a 3.7-fold increase in expression between cases and controls (P=0.005) and showed a trend of increasing expression between primary melanomas and their matched metastases (P<0.001). In situ hybridization showed expression was in melanoma cells and correlated with expression measured by QRT-PCR (P=0.0005). We used the combined discovery and validation samples to verify the prognostic value of additional candidate microRNAs identified from other studies, and proceeded to analyze miR-200b. We demonstrated that miR-10b and miR-200b showed independent prognostic value (P=0.002 and 0.047, respectively) in multivariable analysis alongside known clinico-pathological prognostic features (eg, Breslow thickness) using a Cox proportional hazards regression model. Furthermore, the addition of these microRNAs to the clinico-pathological features led to an improved regression model with better identification of aggressive thick melanomas. Taken together, these data suggest that miR-10b is a new prognostic microRNA for melanoma and that there could be a place for microRNA analysis in stratifying melanoma for therapy." @default.
• W2227182487 created "2016-06-24" @default.
• W2227182487 creator A5004068726 @default.
• W2227182487 creator A5016480307 @default.
• W2227182487 creator A5019907346 @default.
• W2227182487 creator A5049699789 @default.
• W2227182487 creator A5054426602 @default.
• W2227182487 creator A5055358848 @default.
• W2227182487 creator A5066332611 @default.
• W2227182487 date "2016-02-01" @default.
• W2227182487 modified "2023-10-03" @default.
• W2227182487 title "microRNA-10b is a prognostic biomarker for melanoma" @default.
• W2227182487 cites W144423133 @default.
• W2227182487 cites W1577577364 @default.
• W2227182487 cites W1927235213 @default.
• W2227182487 cites W1965551706 @default.
• W2227182487 cites W1967135832 @default.
• W2227182487 cites W1967342065 @default.
• W2227182487 cites W1970332531 @default.
• W2227182487 cites W1972380031 @default.
• W2227182487 cites W1987884300 @default.
• W2227182487 cites W1989892200 @default.
• W2227182487 cites W1994061059 @default.
• W2227182487 cites W2016411222 @default.
• W2227182487 cites W2019310886 @default.
• W2227182487 cites W2022744254 @default.
• W2227182487 cites W2026338982 @default.
• W2227182487 cites W2026986677 @default.
• W2227182487 cites W2027987606 @default.
• W2227182487 cites W2030712838 @default.
• W2227182487 cites W2033993004 @default.
• W2227182487 cites W2036672958 @default.
• W2227182487 cites W2047529648 @default.
• W2227182487 cites W2053863057 @default.
• W2227182487 cites W2055050962 @default.
• W2227182487 cites W2061650731 @default.
• W2227182487 cites W2065122738 @default.
• W2227182487 cites W2066399021 @default.
• W2227182487 cites W2073624652 @default.
• W2227182487 cites W2077494872 @default.
• W2227182487 cites W2090387552 @default.
• W2227182487 cites W2098800316 @default.
• W2227182487 cites W2104956231 @default.
• W2227182487 cites W2105423509 @default.
• W2227182487 cites W2123680400 @default.
• W2227182487 cites W2129615821 @default.
• W2227182487 cites W2135314242 @default.
• W2227182487 cites W2137250828 @default.
• W2227182487 cites W2159888101 @default.
• W2227182487 cites W2161222316 @default.
• W2227182487 cites W2162489334 @default.
• W2227182487 cites W2223734406 @default.
• W2227182487 cites W2322168752 @default.
• W2227182487 cites W2366142655 @default.
• W2227182487 cites W4376562502 @default.
• W2227182487 doi "https://doi.org/10.1038/modpathol.2015.149" @default.
• W2227182487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26743475" @default.
• W2227182487 hasPublicationYear "2016" @default.
• W2227182487 type Work @default.
• W2227182487 sameAs 2227182487 @default.
• W2227182487 citedByCount "37" @default.
• W2227182487 countsByYear W22271824872016 @default.
• W2227182487 countsByYear W22271824872017 @default.
• W2227182487 countsByYear W22271824872018 @default.
• W2227182487 countsByYear W22271824872019 @default.
• W2227182487 countsByYear W22271824872020 @default.
• W2227182487 countsByYear W22271824872021 @default.
• W2227182487 countsByYear W22271824872022 @default.
• W2227182487 countsByYear W22271824872023 @default.
• W2227182487 crossrefType "journal-article" @default.
• W2227182487 hasAuthorship W2227182487A5004068726 @default.
• W2227182487 hasAuthorship W2227182487A5016480307 @default.
• W2227182487 hasAuthorship W2227182487A5019907346 @default.
• W2227182487 hasAuthorship W2227182487A5049699789 @default.
• W2227182487 hasAuthorship W2227182487A5054426602 @default.
• W2227182487 hasAuthorship W2227182487A5055358848 @default.
• W2227182487 hasAuthorship W2227182487A5066332611 @default.
• W2227182487 hasBestOaLocation W22271824871 @default.
• W2227182487 hasConcept C104317684 @default.
• W2227182487 hasConcept C121608353 @default.
• W2227182487 hasConcept C126322002 @default.
• W2227182487 hasConcept C142724271 @default.
• W2227182487 hasConcept C143998085 @default.
• W2227182487 hasConcept C145059251 @default.
• W2227182487 hasConcept C207886595 @default.
• W2227182487 hasConcept C2777658100 @default.
• W2227182487 hasConcept C2777863537 @default.
• W2227182487 hasConcept C2777982462 @default.
• W2227182487 hasConcept C2779013556 @default.
• W2227182487 hasConcept C2781197716 @default.
• W2227182487 hasConcept C48023723 @default.
• W2227182487 hasConcept C502942594 @default.
• W2227182487 hasConcept C55493867 @default.
• W2227182487 hasConcept C71924100 @default.
• W2227182487 hasConcept C86803240 @default.
• W2227182487 hasConceptScore W2227182487C104317684 @default.
• W2227182487 hasConceptScore W2227182487C121608353 @default.
• W2227182487 hasConceptScore W2227182487C126322002 @default.

• next