FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227189367> ?p ?o ?g. }

• W2227189367 endingPage "1394" @default.
• W2227189367 startingPage "1386" @default.
• W2227189367 abstract "Convergent evidence implicates regional neural responses to reward anticipation in the pathogenesis of several psychiatric disorders, such as schizophrenia, where blunted ventral striatal responses to positive reward are observed in patients and at-risk populations. In vivo oxygen amperometry measurements in the ventral striatum in awake, behaving rats reveal reward-related tissue oxygen changes that closely parallel blood oxygen level dependent (BOLD) signal changes observed in human functional magnetic resonance imaging (fMRI), suggesting that a cross-species approach targeting this mechanism might be feasible in psychopharmacology. The present study explored modulatory effects of acute, subanaesthetic doses of ketamine-a pharmacological model widely used in psychopharmacological research, both preclinically and clinically-on ventral striatum activity during performance of a reward anticipation task in both species, using fMRI in humans and in vivo oxygen amperometry in rats. In a region-of-interest analysis conducted following a cross-over placebo and ketamine study in human subjects, an attenuated ventral striatal response during reward anticipation was observed following ketamine relative to placebo during performance of a monetary incentive delay task. In rats, a comparable attenuation of ventral striatal signal was found after ketamine challenge, relative to vehicle, in response to a conditioned stimulus that predicted delivery of reward. This study provides the first data in both species demonstrating an attenuating effect of acute ketamine on reward-related ventral striatal (O2) and fMRI signals. These findings may help elucidate a deeper mechanistic understanding of the potential role of ketamine as a model for psychosis, show that cross-species pharmacological experiments targeting reward signaling are feasible, and suggest this phenotype as a promising translational biomarker for the development of novel compounds, assessment of disease status, and treatment efficacy." @default.
• W2227189367 created "2016-06-24" @default.
• W2227189367 creator A5005872750 @default.
• W2227189367 creator A5006015276 @default.
• W2227189367 creator A5007527904 @default.
• W2227189367 creator A5009057677 @default.
• W2227189367 creator A5022810026 @default.
• W2227189367 creator A5026739428 @default.
• W2227189367 creator A5034002799 @default.
• W2227189367 creator A5037306868 @default.
• W2227189367 creator A5040975353 @default.
• W2227189367 creator A5061863734 @default.
• W2227189367 creator A5083764008 @default.
• W2227189367 date "2015-09-21" @default.
• W2227189367 modified "2023-10-18" @default.
• W2227189367 title "Ketamine Suppresses the Ventral Striatal Response to Reward Anticipation: A Cross-Species Translational Neuroimaging Study" @default.
• W2227189367 cites W1914381346 @default.
• W2227189367 cites W1964807622 @default.
• W2227189367 cites W1985704535 @default.
• W2227189367 cites W1986795023 @default.
• W2227189367 cites W1995111040 @default.
• W2227189367 cites W2001003983 @default.
• W2227189367 cites W2003982930 @default.
• W2227189367 cites W2004416831 @default.
• W2227189367 cites W2008300525 @default.
• W2227189367 cites W2008908272 @default.
• W2227189367 cites W2009570830 @default.
• W2227189367 cites W2019854455 @default.
• W2227189367 cites W2022130624 @default.
• W2227189367 cites W2022490111 @default.
• W2227189367 cites W2028884770 @default.
• W2227189367 cites W2043486705 @default.
• W2227189367 cites W2047614950 @default.
• W2227189367 cites W2048707777 @default.
• W2227189367 cites W2049139447 @default.
• W2227189367 cites W2049335468 @default.
• W2227189367 cites W2055661286 @default.
• W2227189367 cites W2059467168 @default.
• W2227189367 cites W2068772097 @default.
• W2227189367 cites W2084331056 @default.
• W2227189367 cites W2091238585 @default.
• W2227189367 cites W2096684870 @default.
• W2227189367 cites W2099173431 @default.
• W2227189367 cites W2106636235 @default.
• W2227189367 cites W2108403304 @default.
• W2227189367 cites W2113067674 @default.
• W2227189367 cites W2117726420 @default.
• W2227189367 cites W2119128116 @default.
• W2227189367 cites W2124611764 @default.
• W2227189367 cites W2127734905 @default.
• W2227189367 cites W2129028793 @default.
• W2227189367 cites W2137827713 @default.
• W2227189367 cites W2141927127 @default.
• W2227189367 cites W2160518862 @default.
• W2227189367 cites W2441319197 @default.
• W2227189367 cites W91786246 @default.
• W2227189367 doi "https://doi.org/10.1038/npp.2015.291" @default.
• W2227189367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4793123" @default.
• W2227189367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26388147" @default.
• W2227189367 hasPublicationYear "2015" @default.
• W2227189367 type Work @default.
• W2227189367 sameAs 2227189367 @default.
• W2227189367 citedByCount "27" @default.
• W2227189367 countsByYear W22271893672016 @default.
• W2227189367 countsByYear W22271893672017 @default.
• W2227189367 countsByYear W22271893672018 @default.
• W2227189367 countsByYear W22271893672020 @default.
• W2227189367 countsByYear W22271893672021 @default.
• W2227189367 countsByYear W22271893672022 @default.
• W2227189367 countsByYear W22271893672023 @default.
• W2227189367 crossrefType "journal-article" @default.
• W2227189367 hasAuthorship W2227189367A5005872750 @default.
• W2227189367 hasAuthorship W2227189367A5006015276 @default.
• W2227189367 hasAuthorship W2227189367A5007527904 @default.
• W2227189367 hasAuthorship W2227189367A5009057677 @default.
• W2227189367 hasAuthorship W2227189367A5022810026 @default.
• W2227189367 hasAuthorship W2227189367A5026739428 @default.
• W2227189367 hasAuthorship W2227189367A5034002799 @default.
• W2227189367 hasAuthorship W2227189367A5037306868 @default.
• W2227189367 hasAuthorship W2227189367A5040975353 @default.
• W2227189367 hasAuthorship W2227189367A5061863734 @default.
• W2227189367 hasAuthorship W2227189367A5083764008 @default.
• W2227189367 hasBestOaLocation W22271893671 @default.
• W2227189367 hasConcept C118552586 @default.
• W2227189367 hasConcept C126322002 @default.
• W2227189367 hasConcept C154945302 @default.
• W2227189367 hasConcept C15744967 @default.
• W2227189367 hasConcept C169760540 @default.
• W2227189367 hasConcept C170493617 @default.
• W2227189367 hasConcept C176777502 @default.
• W2227189367 hasConcept C2776743251 @default.
• W2227189367 hasConcept C2779226451 @default.
• W2227189367 hasConcept C2779727114 @default.
• W2227189367 hasConcept C2780062018 @default.
• W2227189367 hasConcept C2780795376 @default.
• W2227189367 hasConcept C41008148 @default.
• W2227189367 hasConcept C513476851 @default.
• W2227189367 hasConcept C58693492 @default.

• next