Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227205887> ?p ?o ?g. }
- W2227205887 endingPage "620" @default.
- W2227205887 startingPage "611" @default.
- W2227205887 abstract "Long-distance intracellular transport of organelles, mRNA, and proteins (cargo) occurs along the microtubule cytoskeleton by the action of kinesin and dynein motor proteins, but the vast network of factors involved in regulating intracellular cargo transport are still unknown. We capitalize on the Drosophila melanogaster S2 model cell system to monitor lysosome transport along microtubule bundles, which require enzymatically active kinesin-1 motor protein for their formation. We use an automated tracking program and a naive Bayesian classifier for the multivariate motility data to analyze 15,683 gene phenotypes and find 98 proteins involved in regulating lysosome motility along microtubules and 48 involved in the formation of microtubule filled processes in S2 cells. We identify innate immunity genes, ion channels, and signaling proteins having a role in lysosome motility regulation and find an unexpected relationship between the dynein motor, Rab7a, and lysosome motility regulation." @default.
- W2227205887 created "2016-06-24" @default.
- W2227205887 creator A5014879059 @default.
- W2227205887 creator A5017590197 @default.
- W2227205887 creator A5028181302 @default.
- W2227205887 creator A5029165497 @default.
- W2227205887 creator A5031651397 @default.
- W2227205887 creator A5033899417 @default.
- W2227205887 creator A5038423276 @default.
- W2227205887 creator A5045284572 @default.
- W2227205887 creator A5052473265 @default.
- W2227205887 creator A5062826890 @default.
- W2227205887 creator A5075616182 @default.
- W2227205887 creator A5076095385 @default.
- W2227205887 creator A5078234410 @default.
- W2227205887 creator A5089017047 @default.
- W2227205887 date "2016-01-01" @default.
- W2227205887 modified "2023-10-18" @default.
- W2227205887 title "A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells" @default.
- W2227205887 cites W1568083789 @default.
- W2227205887 cites W1715906171 @default.
- W2227205887 cites W1841826782 @default.
- W2227205887 cites W1966138026 @default.
- W2227205887 cites W1972398314 @default.
- W2227205887 cites W1973590095 @default.
- W2227205887 cites W1978013295 @default.
- W2227205887 cites W1984486913 @default.
- W2227205887 cites W1993761171 @default.
- W2227205887 cites W2011924132 @default.
- W2227205887 cites W2033797646 @default.
- W2227205887 cites W2042992389 @default.
- W2227205887 cites W2052268633 @default.
- W2227205887 cites W2062730710 @default.
- W2227205887 cites W2070506878 @default.
- W2227205887 cites W2072335754 @default.
- W2227205887 cites W2076660375 @default.
- W2227205887 cites W2085242832 @default.
- W2227205887 cites W2085796374 @default.
- W2227205887 cites W2086698861 @default.
- W2227205887 cites W2089053777 @default.
- W2227205887 cites W2096320880 @default.
- W2227205887 cites W2098718365 @default.
- W2227205887 cites W2100334298 @default.
- W2227205887 cites W2103706175 @default.
- W2227205887 cites W2106117608 @default.
- W2227205887 cites W2107554012 @default.
- W2227205887 cites W2108175824 @default.
- W2227205887 cites W2115228628 @default.
- W2227205887 cites W2119564290 @default.
- W2227205887 cites W2132550454 @default.
- W2227205887 cites W2133059825 @default.
- W2227205887 cites W2134810580 @default.
- W2227205887 cites W2135693781 @default.
- W2227205887 cites W2136354065 @default.
- W2227205887 cites W2153698618 @default.
- W2227205887 cites W2160226734 @default.
- W2227205887 cites W2161369215 @default.
- W2227205887 cites W2162897213 @default.
- W2227205887 cites W2167916519 @default.
- W2227205887 cites W2168760539 @default.
- W2227205887 cites W2169432040 @default.
- W2227205887 cites W2314290633 @default.
- W2227205887 cites W1991303664 @default.
- W2227205887 doi "https://doi.org/10.1016/j.celrep.2015.12.051" @default.
- W2227205887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4868501" @default.
- W2227205887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26774481" @default.
- W2227205887 hasPublicationYear "2016" @default.
- W2227205887 type Work @default.
- W2227205887 sameAs 2227205887 @default.
- W2227205887 citedByCount "6" @default.
- W2227205887 countsByYear W22272058872016 @default.
- W2227205887 countsByYear W22272058872021 @default.
- W2227205887 countsByYear W22272058872022 @default.
- W2227205887 countsByYear W22272058872023 @default.
- W2227205887 crossrefType "journal-article" @default.
- W2227205887 hasAuthorship W2227205887A5014879059 @default.
- W2227205887 hasAuthorship W2227205887A5017590197 @default.
- W2227205887 hasAuthorship W2227205887A5028181302 @default.
- W2227205887 hasAuthorship W2227205887A5029165497 @default.
- W2227205887 hasAuthorship W2227205887A5031651397 @default.
- W2227205887 hasAuthorship W2227205887A5033899417 @default.
- W2227205887 hasAuthorship W2227205887A5038423276 @default.
- W2227205887 hasAuthorship W2227205887A5045284572 @default.
- W2227205887 hasAuthorship W2227205887A5052473265 @default.
- W2227205887 hasAuthorship W2227205887A5062826890 @default.
- W2227205887 hasAuthorship W2227205887A5075616182 @default.
- W2227205887 hasAuthorship W2227205887A5076095385 @default.
- W2227205887 hasAuthorship W2227205887A5078234410 @default.
- W2227205887 hasAuthorship W2227205887A5089017047 @default.
- W2227205887 hasBestOaLocation W22272058871 @default.
- W2227205887 hasConcept C104317684 @default.
- W2227205887 hasConcept C106987784 @default.
- W2227205887 hasConcept C134729014 @default.
- W2227205887 hasConcept C166703698 @default.
- W2227205887 hasConcept C181199279 @default.
- W2227205887 hasConcept C20418707 @default.
- W2227205887 hasConcept C2780216420 @default.
- W2227205887 hasConcept C54355233 @default.