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- W2227248522 abstract "Methotrexate has been found to be extensively metabolized to 7-hydroxymethotrexate in patients receiving conventional doses (less than 10 mg/kg) and high doses (greater than 10 mg/kg). Twelve hours after administration, plasma levels of this metabolite in several patients treated with low doses exceeded those of methotrexate. No 7-hydroxymethotrexate was found in CSF after CNS administration of methotrexate; however, small amounts of the metabolite was found in the CSF after intravenous high dose infusion. We conclude that methotrexate is significantly metabolized in man at all doses used clinically." @default.
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- W2227248522 date "1980-06-01" @default.
- W2227248522 modified "2023-09-23" @default.
- W2227248522 title "Metabolism of methotrexate in man after high and conventional doses." @default.
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